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000866697 1001_ $$0P:(DE-Juel1)176653$$aWierckx, Nick$$b0$$eCorresponding author
000866697 245__ $$aMetabolic specialization in itaconic acid production: a tale of two fungi
000866697 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2020
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000866697 520__ $$aSome of the oldest and most established industrial biotechnology processes involve the fungal production of organic acids. In these fungi, the transport of metabolites between cellular compartments, and their secretion, is a major factor. In this review we exemplify the importance of both mitochondrial and plasma membrane transporters in the case of itaconic acid production in two very different fungal systems, Aspergillus and Ustilago. Homologous and heterologous overexpression of both types of transporters, and biochemical analysis of mitochondrial transporter function, show that these two fungi produce the same compound through very different pathways. The way these fungi respond to itaconate stress, especially at low pH, also differs, although this is still an open field which clearly needs additional research.
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000866697 7001_ $$00000-0002-5219-4412$$aAgrimi, Gennaro$$b1
000866697 7001_ $$0P:(DE-HGF)0$$aLübeck, Peter Stephensen$$b2
000866697 7001_ $$0P:(DE-HGF)0$$aSteiger, Matthias G.$$b3
000866697 7001_ $$0P:(DE-HGF)0$$aMira, Nuno Pereira$$b4
000866697 7001_ $$00000-0002-5689-9938$$aPunt, Peter J.$$b5
000866697 773__ $$0PERI:(DE-600)2019676-3$$a10.1016/j.copbio.2019.09.014$$gVol. 62, p. 153 - 159$$p153 - 159$$tCurrent opinion in biotechnology$$v62$$x0958-1669$$y2020
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