TY  - JOUR
AU  - Wierckx, Nick
AU  - Agrimi, Gennaro
AU  - Lübeck, Peter Stephensen
AU  - Steiger, Matthias G.
AU  - Mira, Nuno Pereira
AU  - Punt, Peter J.
TI  - Metabolic specialization in itaconic acid production: a tale of two fungi
JO  - Current opinion in biotechnology
VL  - 62
SN  - 0958-1669
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2019-05772
SP  - 153 - 159
PY  - 2020
N1  - Biotechnologie 1
AB  - Some of the oldest and most established industrial biotechnology processes involve the fungal production of organic acids. In these fungi, the transport of metabolites between cellular compartments, and their secretion, is a major factor. In this review we exemplify the importance of both mitochondrial and plasma membrane transporters in the case of itaconic acid production in two very different fungal systems, Aspergillus and Ustilago. Homologous and heterologous overexpression of both types of transporters, and biochemical analysis of mitochondrial transporter function, show that these two fungi produce the same compound through very different pathways. The way these fungi respond to itaconate stress, especially at low pH, also differs, although this is still an open field which clearly needs additional research.
LB  - PUB:(DE-HGF)16
C6  - pmid:31689647
UR  - <Go to ISI:>//WOS:000530659900022
DO  - DOI:10.1016/j.copbio.2019.09.014
UR  - https://juser.fz-juelich.de/record/866697
ER  -