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@ARTICLE{Wierckx:866697,
      author       = {Wierckx, Nick and Agrimi, Gennaro and Lübeck, Peter
                      Stephensen and Steiger, Matthias G. and Mira, Nuno Pereira
                      and Punt, Peter J.},
      title        = {{M}etabolic specialization in itaconic acid production: a
                      tale of two fungi},
      journal      = {Current opinion in biotechnology},
      volume       = {62},
      issn         = {0958-1669},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2019-05772},
      pages        = {153 - 159},
      year         = {2020},
      note         = {Biotechnologie 1},
      abstract     = {Some of the oldest and most established industrial
                      biotechnology processes involve the fungal production of
                      organic acids. In these fungi, the transport of metabolites
                      between cellular compartments, and their secretion, is a
                      major factor. In this review we exemplify the importance of
                      both mitochondrial and plasma membrane transporters in the
                      case of itaconic acid production in two very different
                      fungal systems, Aspergillus and Ustilago. Homologous and
                      heterologous overexpression of both types of transporters,
                      and biochemical analysis of mitochondrial transporter
                      function, show that these two fungi produce the same
                      compound through very different pathways. The way these
                      fungi respond to itaconate stress, especially at low pH,
                      also differs, although this is still an open field which
                      clearly needs additional research.},
      cin          = {IBG-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {581 - Biotechnology (POF3-581)},
      pid          = {G:(DE-HGF)POF3-581},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31689647},
      UT           = {WOS:000530659900022},
      doi          = {10.1016/j.copbio.2019.09.014},
      url          = {https://juser.fz-juelich.de/record/866697},
}