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000866736 1001_ $$0P:(DE-HGF)0$$aBeguin, Estelle$$b0$$eFirst author
000866736 245__ $$aMagnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device
000866736 260__ $$aNew York, NY [u.a.]$$bElsevier$$c2020
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000866736 500__ $$a© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
000866736 520__ $$aRecent pre-clinical studies have demonstrated the potential of combining chemotherapy and sonodynamic therapy for the treatment of pancreatic cancer. Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a previous study identified a significant practical challenge regarding the co-alignment of the magnetic and ultrasound fields. The aim of this study was to determine whether this challenge could be addressed through the use of a magnetic-acoustic device (MAD) combining a magnetic array and ultrasound transducer in a single unit, to simultaneously concentrate and activate the microbubbles at the target site. in vitro experiments were performed in tissue phantoms and followed by in vivo treatment of xenograft pancreatic cancer (BxPC-3) tumours in a murine model. In vitro, a 1.4-fold (p < .01) increase in the deposition of a model therapeutic payload within the phantom was achieved using the MAD compared to separate magnetic and ultrasound devices. In vivo, tumours treated with the MAD had a 9% smaller mean volume 8 days after treatment, while tumours treated with separate devices or microbubbles alone were respectively 45% and 112% larger. This substantial and sustained decrease in tumour volume suggests that the proposed drug delivery approach has the potential to be an effective neoadjuvant therapy for pancreatic cancer patients.
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000866736 7001_ $$0P:(DE-HGF)0$$aGray, Michael D.$$b1$$eFirst author
000866736 7001_ $$0P:(DE-HGF)0$$aLogan, Keiran A.$$b2$$eFirst author
000866736 7001_ $$0P:(DE-HGF)0$$aNesbitt, Heather$$b3
000866736 7001_ $$0P:(DE-HGF)0$$aSheng, Yingjie$$b4
000866736 7001_ $$0P:(DE-HGF)0$$aKamila, Sukanta$$b5
000866736 7001_ $$0P:(DE-Juel1)172014$$aBarnsley, Lester C.$$b6$$ufzj
000866736 7001_ $$0P:(DE-HGF)0$$aBau, Luca$$b7
000866736 7001_ $$0P:(DE-HGF)0$$aMcHale, Anthony P.$$b8
000866736 7001_ $$0P:(DE-HGF)0$$aCallan, John F.$$b9
000866736 7001_ $$00000-0003-3371-5929$$aStride, Eleanor$$b10$$eCorresponding author
000866736 773__ $$0PERI:(DE-600)1482453-x$$a10.1016/j.jconrel.2019.11.013$$gVol. 317, p. 23 - 33$$p23 - 33$$tJournal of controlled release$$v317$$x0168-3659$$y2020
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