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@ARTICLE{Beguin:866736,
      author       = {Beguin, Estelle and Gray, Michael D. and Logan, Keiran A.
                      and Nesbitt, Heather and Sheng, Yingjie and Kamila, Sukanta
                      and Barnsley, Lester C. and Bau, Luca and McHale, Anthony P.
                      and Callan, John F. and Stride, Eleanor},
      title        = {{M}agnetic microbubble mediated chemo-sonodynamic therapy
                      using a combined magnetic-acoustic device},
      journal      = {Journal of controlled release},
      volume       = {317},
      issn         = {0168-3659},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2019-05805},
      pages        = {23 - 33},
      year         = {2020},
      note         = {© 2019 The Authors. Published by Elsevier B.V. This is an
                      open access article under the CC BY license
                      (http://creativecommons.org/licenses/BY/4.0/).},
      abstract     = {Recent pre-clinical studies have demonstrated the potential
                      of combining chemotherapy and sonodynamic therapy for the
                      treatment of pancreatic cancer. Oxygen-loaded magnetic
                      microbubbles have been explored as a targeted delivery
                      vehicle for this application. Despite preliminary positive
                      results, a previous study identified a significant practical
                      challenge regarding the co-alignment of the magnetic and
                      ultrasound fields. The aim of this study was to determine
                      whether this challenge could be addressed through the use of
                      a magnetic-acoustic device (MAD) combining a magnetic array
                      and ultrasound transducer in a single unit, to
                      simultaneously concentrate and activate the microbubbles at
                      the target site. in vitro experiments were performed in
                      tissue phantoms and followed by in vivo treatment of
                      xenograft pancreatic cancer (BxPC-3) tumours in a murine
                      model. In vitro, a 1.4-fold (p < .01) increase in the
                      deposition of a model therapeutic payload within the phantom
                      was achieved using the MAD compared to separate magnetic and
                      ultrasound devices. In vivo, tumours treated with the MAD
                      had a $9\%$ smaller mean volume 8 days after treatment,
                      while tumours treated with separate devices or microbubbles
                      alone were respectively $45\%$ and $112\%$ larger. This
                      substantial and sustained decrease in tumour volume suggests
                      that the proposed drug delivery approach has the potential
                      to be an effective neoadjuvant therapy for pancreatic cancer
                      patients.},
      cin          = {JCNS-FRM-II / JCNS-1 / MLZ},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31733295},
      UT           = {WOS:000512730700002},
      doi          = {10.1016/j.jconrel.2019.11.013},
      url          = {https://juser.fz-juelich.de/record/866736},
}