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@ARTICLE{Wiedenhft:866920,
      author       = {Wiedenhöft, Tabea and Tarantini, Stefano and Nyul-Toth,
                      Adam and Yabluchanskiy, Andriy},
      title        = {{F}usogenic liposomes effectively deliver resveratrol to
                      the cerebral microcirculation and improve
                      endothelium-dependent neurovascular coupling responses in
                      aged mice},
      journal      = {GeroScience},
      volume       = {41},
      issn         = {2509-2715},
      address      = {[Cham]},
      publisher    = {Springer International Publishing},
      reportid     = {FZJ-2019-05973},
      pages        = {711–725},
      year         = {2019},
      abstract     = {Adjustment of cerebral blood flow (CBF) to the increased
                      oxygen and nutrient demands of active brain regions via
                      neurovascular coupling (NVC) has an essential role in
                      maintenance of healthy cognitive function. In advanced age,
                      cerebromicrovascular oxidative stress and endothelial
                      dysfunction impair neurovascular coupling, contributing to
                      age-related cognitive decline. Recently we developed a
                      resveratrol (3,4′,5-trihydroxystilbene)-containing
                      fusogenic liposome (FL-RSV)-based molecular delivery system
                      that can effectively target cultured cerebromicrovascular
                      endothelial cells, attenuating age-related oxidative stress.
                      To assess the cerebromicrovascular protective effects of
                      FL-RSV in vivo, aged (24-month-old) C57BL/6 mice were
                      treated with FL-RSV for four days. To demonstrate effective
                      cellular uptake of FL-RSV, accumulation of the lipophilic
                      tracer dyes in cells of the neurovascular unit was confirmed
                      using two-photon imaging (through a chronic cranial window).
                      NVC was assessed by measuring CBF responses (laser speckle
                      contrast imaging) evoked by contralateral whisker
                      stimulation. We found that NVC responses were significantly
                      impaired in aged mice. Treatment with FL-RSV significantly
                      improved NVC responses by increasing NO-mediated
                      vasodilation. These findings are paralleled by the
                      protective effects of FL-RSV on endothelium-dependent
                      relaxation in the aorta. Thus, treatment with FL-RSV rescues
                      endothelial function and NVC responses in aged mice. We
                      propose that resveratrol containing fusogenic liposomes
                      could also be used for combined delivery of various
                      anti-geronic factors, including proteins, small molecules,
                      DNA vectors and mRNAs targeting key pathways involved in
                      microvascular aging and neurovascular dysfunction for the
                      prevention/treatment of age-related cerebromicrovascular
                      pathologies and development of vascular cognitive impairment
                      (VCI) in aging.},
      cin          = {ICS-7 / IBI-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-7-20110106 / I:(DE-Juel1)IBI-2-20200312},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31654270},
      UT           = {WOS:000492573700002},
      doi          = {10.1007/s11357-019-00102-1},
      url          = {https://juser.fz-juelich.de/record/866920},
}