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@ARTICLE{Russo:867572,
      author       = {Russo, Daniela and de Angelis, Andrea and Garvey,
                      Christopher. J. and Wurm, Frederick R. and Appavou,
                      Marie-Sousai and Prevost, Sylvain},
      title        = {{E}ffect of {P}olymer {C}hain {D}ensity on
                      {P}rotein–{P}olymer {C}onjugate {C}onformation},
      journal      = {Biomacromolecules},
      volume       = {20},
      number       = {5},
      issn         = {1526-4602},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Soc.},
      reportid     = {FZJ-2019-06195},
      pages        = {1944 - 1955},
      year         = {2019},
      abstract     = {Many biomedical applications employ covalent attachment to
                      synthetic polymers to enhance the efficiency of proteins or
                      other therapeutically active molecules. We report here the
                      impact of polymer conjugation on the structural and thermal
                      stability of a protein model, the bovine serum albumin,
                      using a variable number of linear biodegradable
                      polyphosphoesters, which were covalently tethered to the
                      protein. We observed that BSA’s secondary structure
                      measured by circular dichroism is independent of the
                      conjugation. Small-angle neutron scattering, however,
                      reveals a change from ellipsoid to globular shape of the
                      whole complex arising from a slight compaction of the
                      protein core and an increase of the polymer’s radius of
                      gyration as a function of the grafting polymer density. In
                      particular, we highlight a gradual change of the polymer
                      conformation around the protein and elongation of the
                      semimajor dimension of the ellipsoidal protein. Our results
                      will contribute to the description of biophysical
                      characteristics of a new class of biologically relevant
                      protein–polymer conjugates},
      cin          = {JCNS-FRM-II / JCNS-1 / MLZ},
      ddc          = {570},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30933481},
      UT           = {WOS:000468120800011},
      doi          = {10.1021/acs.biomac.9b00184},
      url          = {https://juser.fz-juelich.de/record/867572},
}