Home > Publications database > Experimental validation of biocompatible nanostructured lipid carriers of sophorolipid: Optimization, characterization and in-vitro evaluation > print

001     867577
005     20210130003804.0
024 7 _ |a 10.1016/j.colsurfb.2019.06.036
|2 doi
024 7 _ |a 0927-7765
|2 ISSN
024 7 _ |a 1873-4367
|2 ISSN
024 7 _ |a pmid:31254745
|2 pmid
024 7 _ |a WOS:000481565300098
|2 WOS
037 _ _ |a FZJ-2019-06200
082 _ _ |a 540
100 1 _ |a Kanwar, Rohini
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Experimental validation of biocompatible nanostructured lipid carriers of sophorolipid: Optimization, characterization and in-vitro evaluation
260 _ _ |a [S.l.]
|c 2019
|b Science Direct
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1586004920_29483
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a To date, the potential of sophorolipids (an important class of glycolipids) has been exploited solely as amphipathic molecules but their ability to formulate lipid nanoparticles has never been explored. In this report, for the first time, lipid nanostructures coated with polysorbates (Tweens) were formulated by a hot dispersion method. By varying the amount of lipid, type of surfactant, and alcohol, dilution ratio etc., the formulation was optimized with respect to its stability, which is a central aspect of their potential applications. Their comprehensive physicochemical characterization was done using static and dynamic light scattering (SLS, DLS), small angle neutron scattering (SANS), zeta-potential, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic force microscopy (AFM) techniques. Further hemolysis study was conducted to understand the in-vitro cytotoxicity levels of the lipidic nanoparticles prior to its application as a potent drug delivery device for countermanding the problems associated with challenging tuberculosis and leprosy drug-Rifampicin. Attaining high entrapment efficiency and sustained release from the developed carrier, further interaction with bovine serum albumin was investigated, to understand the in-vivo behavior of the nanostructured lipid carriers (NLCs).
536 _ _ |a 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
|0 G:(DE-HGF)POF3-6G4
|c POF3-623
|f POF III
|x 0
536 _ _ |0 G:(DE-HGF)POF3-6G15
|f POF III
|x 1
|c POF3-6G15
|a 6G15 - FRM II / MLZ (POF3-6G15)
588 _ _ |a Dataset connected to CrossRef
650 2 7 |a Soft Condensed Matter
|0 V:(DE-MLZ)SciArea-210
|2 V:(DE-HGF)
|x 0
650 1 7 |a Polymers, Soft Nano Particles and Proteins
|0 V:(DE-MLZ)GC-1602-2016
|2 V:(DE-HGF)
|x 0
693 _ _ |a Forschungs-Neutronenquelle Heinz Maier-Leibnitz
|e KWS-1: Small angle scattering diffractometer
|f NL3b
|1 EXP:(DE-MLZ)FRMII-20140101
|0 EXP:(DE-MLZ)KWS1-20140101
|5 EXP:(DE-MLZ)KWS1-20140101
|6 EXP:(DE-MLZ)NL3b-20140101
|x 0
700 1 _ |a Gradzielski, Michael
|0 0000-0002-7262-7115
|b 1
|e Corresponding author
700 1 _ |a Prevost, Sylvain
|0 0000-0002-6008-1987
|b 2
700 1 _ |a Appavou, Marie-Sousai
|0 P:(DE-Juel1)130507
|b 3
|u fzj
700 1 _ |a Mehta, S. K.
|0 0000-0002-7140-6900
|b 4
|e Corresponding author
773 _ _ |a 10.1016/j.colsurfb.2019.06.036
|g Vol. 181, p. 845 - 855
|0 PERI:(DE-600)1500523-9
|p 845 - 855
|t Colloids and surfaces / B Biointerfaces B
|v 181
|y 2019
|x 0927-7765
909 C O |o oai:juser.fz-juelich.de:867577
|p VDB:MLZ
|p VDB
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 3
|6 P:(DE-Juel1)130507
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 4
|6 0000-0002-7140-6900
913 1 _ |a DE-HGF
|b Forschungsbereich Materie
|l Von Materie zu Materialien und Leben
|1 G:(DE-HGF)POF3-620
|0 G:(DE-HGF)POF3-623
|2 G:(DE-HGF)POF3-600
|v Facility topic: Neutrons for Research on Condensed Matter
|9 G:(DE-HGF)POF3-6G4
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
913 1 _ |a DE-HGF
|9 G:(DE-HGF)POF3-6G15
|x 1
|4 G:(DE-HGF)POF
|v FRM II / MLZ
|1 G:(DE-HGF)POF3-6G0
|0 G:(DE-HGF)POF3-6G15
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-600
|b Forschungsbereich Materie
|l Großgeräte: Materie
914 1 _ |y 2019
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b COLLOID SURFACE B : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)JCNS-FRM-II-20110218
|k JCNS-FRM-II
|l JCNS-FRM-II
|x 0
920 1 _ |0 I:(DE-Juel1)JCNS-1-20110106
|k JCNS-1
|l Neutronenstreuung
|x 1
920 1 _ |0 I:(DE-588b)4597118-3
|k MLZ
|l Heinz Maier-Leibnitz Zentrum
|x 2
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-Juel1)JCNS-FRM-II-20110218
980 _ _ |a I:(DE-Juel1)JCNS-1-20110106
980 _ _ |a I:(DE-588b)4597118-3
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21