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@ARTICLE{Kanwar:867578,
      author       = {Kanwar, Rohini and Gradzielski, Michael and Prevost,
                      Sylvain and Kaur, Gurpreet and Appavou, Marie-Sousai and
                      Mehta, S. K.},
      title        = {{P}hysicochemical stimuli as tuning parameters to modulate
                      the structure and stability of nanostructured lipid carriers
                      and release kinetics of encapsulated antileprosy drugs},
      journal      = {Journal of materials chemistry / B Materials for biology
                      and medicine B},
      volume       = {7},
      number       = {42},
      issn         = {2050-7518},
      address      = {London ˜[u.a.]œ},
      publisher    = {RSC},
      reportid     = {FZJ-2019-06201},
      pages        = {6539 - 6555},
      year         = {2019},
      abstract     = {To unveil the effect of electrolyte concentration, pH and
                      polymer addition on Tween 80 stabilized nanostructured lipid
                      carriers (NLCs, based on dialkyldimethylammonium bromides
                      DxDAB and Na oleate), an in-depth scattering analysis was
                      performed. Dynamic and static light scattering (DLS/SLS) and
                      small-angle neutron scattering (SANS) techniques along with
                      zeta potential studies were exploited to understand the
                      structural evolution and physical stability of NLCs. In
                      these experiments, we varied the salt concentration, pH, and
                      the admixture of Pluronic F127 in order to elucidate their
                      effect on NLC morphologies. In most cases, two populations
                      of different sizes are present which differ by one order of
                      magnitude. The antileprosy drugs (ALD) Rifampicin and
                      Dapsone were encapsulated in NLCs and the vector properties
                      were assessed for a series of DxDAB (where x = 12, 14, 16
                      and 18) NLCs. The influence of composition on the entrapment
                      and release behavior of NLCs was investigated: The size of
                      NLCs correlates with the release rate of the incorporated
                      drug. The interaction of drug-loaded NLCs with bovine serum
                      albumin was studied to understand the release of ALD in the
                      plasma.},
      cin          = {JCNS-FRM-II / JCNS-1 / MLZ},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31584603},
      UT           = {WOS:000493525000006},
      doi          = {10.1039/C9TB01330J},
      url          = {https://juser.fz-juelich.de/record/867578},
}