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@ARTICLE{Andlauer:867598,
author = {Andlauer, Till F M and Guzman-Parra, Jose and Streit,
Fabian and Strohmaier, Jana and González, Maria José and
Gil Flores, Susana and Cabaleiro Fabeiro, Francisco J and
Del Río Noriega, Francisco and Perez, Fermin Perez and Haro
González, Jesus and Orozco Diaz, Guillermo and de
Diego-Otero, Yolanda and Moreno-Küstner, Berta and
Auburger, Georg and Degenhardt, Franziska and
Heilmann-Heimbach, Stefanie and Herms, Stefan and Hoffmann,
Per and Frank, Josef and Foo, Jerome C and Treutlein, Jens
and Witt, Stephanie H and Cichon, Sven and Kogevinas,
Manolis and Rivas, Fabio and Mayoral, Fermín and
Müller-Myhsok, Bertram and Forstner, Andreas J and Nöthen,
Markus M and Rietschel, Marcella and Stahl, Eli A and Breen,
Gerome and Forstner, Andreas J and McQuillin, Andrew and
Ripke, Stephan and Trubetskoy, Vassily and Mattheisen,
Manuel and Wang, Yunpeng and Coleman, Jonathan R I and
Gaspar, Héléna A and de Leeuw, Christiaan A and Steinberg,
Stacy and Pavlides, Jennifer M Whitehead and Trzaskowski,
Maciej and Pers, Tune H and Holmans, Peter A and Abbott,
Liam and Agerbo, Esben and Akil, Huda and Albani, Diego and
Alliey-Rodriguez, Ney and Als, Thomas D and Anjorin, Adebayo
and Antilla, Verneri and Awasthi, Swapnil and Badner, Judith
A and Bækvad-Hansen, Marie and Barchas, Jack D and Bass,
Nicholas and Bauer, Michael and Belliveau, Richard and
Bergen, Sarah E and Pedersen, Carsten Bøcker and Bøen,
Erlend and Boks, Marco and Boocock, James and Budde, Monika
and Bunney, William and Burmeister, Margit and
Bybjerg-Grauholm, Jonas and Byerley, William and Casas,
Miquel and Cerrato, Felecia and Cervantes, Pablo and
Chambert, Kimberly and Charney, Alexander W and Chen,
Danfeng and Churchhouse, Claire and Clarke, Toni-Kim and
Coryell, William and Craig, David W and Cruceanu, Cristiana
and Czerski, Piotr M and Dale, Anders M and de Jong, Simone
and Degenhardt, Franziska and Del-Favero, Jurgen and
DePaulo, J Raymond and Djurovic, Srdjan and Dobbyn, Amanda L
and Dumont, Ashley and Elvsåshagen, Torbjørn and
Escott-Price, Valentina and Fan, Chun Chieh and Fischer,
Sascha B and Flickinger, Matthew and Foroud, Tatiana M and
Forty, Liz and Frank, Josef and Fraser, Christine and
Freimer, Nelson B and Frisén, Louise and Gade, Katrin and
Gage, Diane and Garnham, Julie and Giambartolomei, Claudia
and Pedersen, Marianne Giørtz and Goldstein, Jaqueline and
Gordon, Scott D and Gordon-Smith, Katherine and Green,
Elaine K and Green, Melissa J and Greenwood, Tiffany A and
Grove, Jakob and Guan, Weihua and Parra, José Guzman and
Hamshere, Marian L and Hautzinger, Martin and Heilbronner,
Urs and Herms, Stefan and Hipolito, Maria and Hoffmann, Per
and Holland, Dominic and Huckins, Laura and Jamain,
Stéphane and Johnson, Jessica S and Juréus, Anders and
Kandaswamy, Radhika and Karlsson, Robert and Kennedy, James
L and Kittel-Schneider, Sarah and Knowles, James A and
Kogevinas, Manolis and Koller, Anna C and Kupka, Ralph and
Lavebratt, Catharina and Lawrence, Jacob and Lawson, William
B and Leber, Markus and Lee, Phil H and Levy, Shawn E and
Li, Jun Z and Liu, Chunyu and Lucae, Susanne and Maaser,
Anna and MacIntyre, Donald J and Mahon, Pamela B and Maier,
Wolfgang and Martinsson, Lina and McCarroll, Steve and
McGuffin, Peter and McInnis, Melvin G and McKay, James D and
Medeiros, Helena and Medland, Sarah E and Meng, Fan and
Milani, Lili and Montgomery, Grant W and Morris, Derek W and
Mühleisen, Thomas W and Mullins, Niamh and Nguyen, Hoang
and Nievergelt, Caroline M and Adolfsson, Annelie Nordin and
Nwulia, Evaristus A and O'Donovan, Claire and Loohuis, Loes
M Olde and Ori, Anil P S and Oruc, Lilijana and Ösby, Urban
and Perlis, Roy H and Perry, Amy and Pfennig, Andrea and
Potash, James B and Purcell, Shaun M and Regeer, Eline J and
Reif, Andreas and Reinbold, Céline S and Rice, John P and
Richards, Alexander L and Rivas, Fabio and Rivera, Margarita
and Roussos, Panos and Ruderfer, Douglas M and Ryu, Euijung
and Sánchez-Mora, Cristina and Schatzberg, Alan F and
Scheftner, William A and Schork, Nicholas J and Weickert,
Cynthia Shannon and Shehktman, Tatyana and Shilling, Paul D
and Sigurdsson, Engilbert and Slaney, Claire and Smeland,
Olav B and Sobell, Janet L and Hansen, Christine Søholm and
Spijker, Anne T and Clair, David St and Steffens, Michael
and Strauss, John S and Streit, Fabian and Strohmaier, Jana
and Szelinger, Szabolcs and Thompson, Robert C and
EThorgeirsson, Thorgeir and Treutlein, Jens and Vedde,
Helmut and Wang, Weiqing and Watson, Stanley J and Weickert,
Thomas W and Witt, Stephanie H and Xi, Simon and Xu, Wei and
Young, Allan H and Zandi, Peter and Zhang, Peng and Zollner,
Sebastian and Adolfsson, Rolf and Agartz, Ingrid and Alda,
Martin and Backlund, Lena and Baune, Bernhard T and
Bellivier, Frank and Berrettini, Wade H and Biernacka,
Joanna M and Blackwood, Douglas H R and Boehnke, Michael and
Børglum, Anders D and Corvin, Aiden and Craddock, Nicholas
and Daly, Mark J and Dannlowski, Udo and Esko, Tõnu and
Etain, Bruno and Frye, Mark and Fullerton, Janice M and
Gershon, Elliot S and Gill, Michael and Goes, Fernando and
Grigoroiu-Serbanescu, Maria and Hauser, Joanna and Hougaard,
David M and Hultman, Christina M and Jones, Ian and Jones,
Lisa A and Kahn, René S and Kirov, George and Landén,
Mikael and Leboyer, Marion and Lewis, Cathryn M and Li,
Qingqin S and Lissowska, Jolanta and Martin, Nicholas G and
Mayoral, Fermin and McElroy, Susan L and McIntosh, Andrew M
and McMahon, Francis J and Melle, Ingrid and Metspalu,
Andres and Mitchell, Philip B and Morken, Gunnar and Mors,
Ole and Mortensen, Preben Bo and Müller-Myhsok, Bertram and
Myers, Richard M and Neale, Benjamin M and Nimgaonkar,
Vishwajit and Nordentoft, Merete and Nöthen, Markus M and
O'Donovan, Michael C and Oedegaard, Ketil J and Owen,
Michael J and Paciga, Sara A and Pato, Carlos and Pato,
Michele T and Posthuma, Danielle and Ramos-Quiroga, Josep
Antoni and Ribasés, Marta and Rietschel, Marcella and
Rouleau, Guy A and Schalling, Martin and Schofield, Peter R
and Schulze, Thomas G and Serretti, Alessandro and Smoller,
Jordan W and Stefansson, Hreinn and Stefansson, Kari and
Stordal, Eystein and Sullivan, Patrick F and Turecki,
Gustavo and Vaaler, Arne E and Vieta, Eduard and Vincent,
John B and Werge, Thomas and Nurnberger, John I and Wray,
Naomi R and Florio, Arianna Di and Edenberg, Howard J and
Cichon, Sven and Ophoff, Roel A and Scott, Laura J and
Andreassen, Ole A and Kelsoe, John and Sklar, Pamela and
Wray, Naomi R and Ripke, Stephan and Mattheisen, Manuel and
Trzaskowski, Maciej and Byrne, Enda M and Abdellaoui, Abdel
and Adams, Mark J and Agerbo, Esben and Air, Tracy M and
Andlauer, Till F M and Bacanu, Silviu-Alin and
Bækvad-Hansen, Marie and Beekman, Aartjan T F and Bigdeli,
Tim B and Binder, Elisabeth B and Bryois, Julien and
Buttenschøn, Henriette N and Bybjerg-Grauholm, Jonas and
Cai, Na and Castelao, Enrique and Christensen, Jane
Hvarregaard and Clarke, Toni-Kim and Coleman, Jonathan R I
and Colodro-Conde, Lucía and Couvy-Duchesne, Baptiste and
Craddock, Nick and Crawford, Gregory E and Davies, Gail and
Deary, Ian J and Degenhardt, Franziska and Derks, Eske M and
Direk, Nese and Dolan, Conor V and Dunn, Erin C and Eley,
Thalia C and Escott-Price, Valentina and Kiadeh, Farnush
Farhadi Hassan and Finucane, Hilary K and Foo, Jerome C and
Forstner, Andreas J and Frank, Josef and Gaspar, Héléna A
and Gill, Michael and Goes, Fernando S and Gordon, Scott D
and Grove, Jakob and Hall, Lynsey S and Hansen, Christine
Søholm and Hansen, Thomas F and Herms, Stefan and Hickie,
Ian B and Hoffmann, Per and Homuth, Georg and Horn, Carsten
and Hottenga, Jouke-Jan and Hougaard, David M and Howard,
David M and Ising, Marcus and Jansen, Rick and Jones, Ian
and Jones, Lisa A and Jorgenson, Eric and Knowles, James A
and Kohane, Isaac S and Kraft, Julia and Kretzschmar, Warren
W and Kutalik, Zoltán and Li, Yihan and Lind, Penelope A
and MacIntyre, Donald J and MacKinnon, Dean F and Maier,
Robert M and Maier, Wolfgang and Marchini, Jonathan and
Mbarek, Hamdi and McGrath, Patrick and McGuffin, Peter and
Medland, Sarah E and Mehta, Divya and Middeldorp, Christel M
and Mihailov, Evelin and Milaneschi, Yuri and Milani, Lili
and Mondimore, Francis M and Montgomery, Grant W and
Mostafavi, Sara and Mullins, Niamh and Nauck, Matthias and
Ng, Bernard and Nivard, Michel G and Nyholt, Dale R and
O'Reilly, Paul F and Oskarsson, Hogni and Owen, Michael J
and Painter, Jodie N and Pedersen, Carsten Bøcker and
Pedersen, Marianne Giørtz and Peterson, Roseann E and
Pettersson, Erik and Peyrot, Wouter J and Pistis, Giorgio
and Posthuma, Danielle and Quiroz, Jorge A and Qvist, Per
and Rice, John P and Riley, Brien P and Rivera, Margarita
and Mirza, Saira Saeed and Schoevers, Robert and Schulte,
Eva C and Shen, Ling and Shi, Jianxin and Shyn, Stanley I
and Sigurdsson, Engilbert and Sinnamon, Grant C B and Smit,
Johannes H and Smith, Daniel J and Stefansson, Hreinn and
Steinberg, Stacy and Streit, Fabian and Strohmaier, Jana and
Tansey, Katherine E and Teismann, Henning and Teumer,
Alexander and Thompson, Wesley and Thomson, Pippa A and
Thorgeirsson, Thorgeir E and Traylor, Matthew and Treutlein,
Jens and Trubetskoy, Vassily and Uitterlinden, André G and
Umbricht, Daniel and Van der Auwera, Sandra and van Hemert,
Albert M and Viktorin, Alexander and Visscher, Peter M and
Wang, Yunpeng and Webb, Bradley T and Weinsheimer, Shantel
Marie and Wellmann, Jürgen and Willemsen, Gonneke and Witt,
Stephanie H and Wu, Yang and Xi, Hualin S and Yang, Jian and
Zhang, Futao and Arolt, Volker and Baune, Bernhard T and
Berger, Klaus and Boomsma, Dorret I and Cichon, Sven and
Dannlowski, Udo and de Geus, E. J. C. and DePaulo, J Raymond
and Domenici, Enrico and Domschke, Katharina and Esko, Tõnu
and Grabe, Hans J and Hamilton, Steven P and Hayward,
Caroline and Heath, Andrew C and Kendler, Kenneth S and
Kloiber, Stefan and Lewis, Glyn and Li, Qingqin S and Lucae,
Susanne and Madden, Pamela A F and Magnusson, Patrik K and
Martin, Nicholas G and McIntosh, Andrew M and Metspalu,
Andres and Mors, Ole and Mortensen, Preben Bo and
Müller-Myhsok, Bertram and Nordentoft, Merete and Nöthen,
Markus M and O'Donovan, Michael C and Paciga, Sara A and
Pedersen, Nancy L and Penninx, Brenda W J H and Perlis, Roy
H and Porteous, David J and Potash, James B and Preisig,
Martin and Rietschel, Marcella and Schaefer, Catherine and
Schulze, Thomas G and Smoller, Jordan W and Stefansson, Kari
and Tiemeier, Henning and Uher, Rudolf and Völzke, Henry
and Weissman, Myrna M and Werge, Thomas and Lewis, Cathryn M
and Levinson, Douglas F and Breen, Gerome and Børglum,
Anders D and Sullivan, Patrick F},
title = {{B}ipolar multiplex families have an increased burden of
common risk variants for psychiatric disorders.},
journal = {Molecular psychiatry},
volume = {26},
issn = {1476-5578},
address = {London},
publisher = {Macmillan},
reportid = {FZJ-2019-06219},
pages = {1286–1298},
year = {2021},
abstract = {Multiplex families with a high prevalence of a psychiatric
disorder are often examined to identify rare genetic
variants with large effect sizes. In the present study, we
analysed whether the risk for bipolar disorder (BD) in BD
multiplex families is influenced by common genetic variants.
Furthermore, we investigated whether this risk is conferred
mainly by BD-specific risk variants or by variants also
associated with the susceptibility to schizophrenia or major
depression. In total, 395 individuals from 33 Andalusian BD
multiplex families (166 BD, 78 major depressive disorder,
151 unaffected) as well as 438 subjects from an independent,
BD case/control cohort (161 unrelated BD, 277 unrelated
controls) were analysed. Polygenic risk scores (PRS) for BD,
schizophrenia (SCZ), and major depression were calculated
and compared between the cohorts. Both the familial BD cases
and unaffected family members had higher PRS for all three
psychiatric disorders than the independent controls, with BD
and SCZ being significant after correction for multiple
testing, suggesting a high baseline risk for several
psychiatric disorders in the families. Moreover, familial BD
cases showed significantly higher BD PRS than unaffected
family members and unrelated BD cases. A plausible
hypothesis is that, in multiplex families with a general
increase in risk for psychiatric disease, BD development is
attributable to a high burden of common variants that confer
a specific risk for BD. The present analyses demonstrated
that common genetic risk variants for psychiatric disorders
are likely to contribute to the high incidence of affective
psychiatric disorders in the multiplex families. However,
the PRS explained only part of the observed phenotypic
variance, and rare variants might have also contributed to
disease development.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31712721},
UT = {WOS:000632144900019},
doi = {10.1038/s41380-019-0558-2},
url = {https://juser.fz-juelich.de/record/867598},
}
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