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@ARTICLE{Rondelli:867731,
      author       = {Rondelli and Cola and Koutsioumpas, Alexandros and Alongi
                      and Ferruti and Ranucci and Brocca},
      title        = {{M}ucin {T}hin {L}ayers: {A} {M}odel for {M}ucus-{C}overed
                      {T}issues},
      journal      = {International journal of molecular sciences},
      volume       = {20},
      number       = {15},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2019-06346},
      pages        = {3712 -},
      year         = {2019},
      abstract     = {The fate of macromolecules of biological or pharmacological
                      interest that enter the mucus barrier is a current field of
                      investigation. Studies of the interaction between the main
                      constituent of mucus, mucins, and molecules involved in
                      topical transmucoidal drug or gene delivery is a
                      prerequisite for nanomedicine design. We studied the
                      interaction of mucin with the bio-inspired arginine-derived
                      amphoteric polymer d,l-ARGO7 by applying complementary
                      techniques. Small angle X-ray scattering in bulk unveiled
                      the formation of hundreds of nanometer-sized clusters, phase
                      separated from the mucin mesh. Quartz microbalance with
                      dissipation and neutron reflectometry measurements on thin
                      mucin layers deposited on silica supports highlighted the
                      occurrence of polymer interaction with mucin on the
                      molecular scale. Rinsing procedures on both experimental set
                      ups showed that interaction induces alteration of the
                      deposited hydrogel. We succeeded in building up a new
                      significant model for epithelial tissues covered by mucus,
                      obtaining the deposition of a mucin layer 20 Å thick on the
                      top of a glycolipid enriched phospholipid single membrane,
                      suitable to be investigated by neutron reflectometry. The
                      model is applicable to unveil the cross structural details
                      of mucus-covered epithelia in interaction with
                      macromolecules within the Å discreteness.},
      cin          = {JCNS-FRM-II / JCNS-1 / MLZ},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)MARIA-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31362433},
      UT           = {WOS:000482383000105},
      doi          = {10.3390/ijms20153712},
      url          = {https://juser.fz-juelich.de/record/867731},
}