%0 Journal Article
%A Galldiks, Norbert
%A Lohmann, Philipp
%A Werner, Jan-Michael
%A Ceccon, Garry
%A Fink, Gereon R.
%A Langen, Karl-Josef
%T Molecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors
%J Expert review of anticancer therapy
%V 20
%N 1
%@ 1744-8328
%C Abingdon, Oxon
%I Taylor & Francis
%M FZJ-2020-00032
%P 9-15
%D 2020
%X Introduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related changes detected by advanced neuroimaging techniques following the most suitable immunotherapy options currently used in neuro-oncology. We, furthermore, provide an overview of how these advanced imaging techniques may help to overcome shortcomings of standard MRI in the assessment and follow-up of patients with brain cancer.Areas covered: The current literature on neuroimaging for immunotherapy in the field of brain tumors, with a focus on gliomas and brain metastases is summarized.Expert commentary: Data suggest that imaging parameters primarily derived from amino acid PET, diffusion- and perfusion-weighted MRI, or MR spectroscopy are particularly helpful for the evaluation of treatment response and provide valuable information for the differentiation of treatment-induced changes from actual brain tumor progression following various immunotherapy approaches.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31842635
%U <Go to ISI:>//WOS:000503931600001
%R 10.1080/14737140.2020.1705788
%U https://juser.fz-juelich.de/record/868438