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000868438 1001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b0$$eCorresponding author$$ufzj
000868438 245__ $$aMolecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors
000868438 260__ $$aAbingdon, Oxon$$bTaylor & Francis$$c2020
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000868438 520__ $$aIntroduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related changes detected by advanced neuroimaging techniques following the most suitable immunotherapy options currently used in neuro-oncology. We, furthermore, provide an overview of how these advanced imaging techniques may help to overcome shortcomings of standard MRI in the assessment and follow-up of patients with brain cancer.Areas covered: The current literature on neuroimaging for immunotherapy in the field of brain tumors, with a focus on gliomas and brain metastases is summarized.Expert commentary: Data suggest that imaging parameters primarily derived from amino acid PET, diffusion- and perfusion-weighted MRI, or MR spectroscopy are particularly helpful for the evaluation of treatment response and provide valuable information for the differentiation of treatment-induced changes from actual brain tumor progression following various immunotherapy approaches.
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000868438 7001_ $$0P:(DE-Juel1)145110$$aLohmann, Philipp$$b1$$ufzj
000868438 7001_ $$0P:(DE-HGF)0$$aWerner, Jan-Michael$$b2
000868438 7001_ $$0P:(DE-HGF)0$$aCeccon, Garry$$b3
000868438 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b4$$ufzj
000868438 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b5$$ufzj
000868438 773__ $$0PERI:(DE-600)2090850-7$$a10.1080/14737140.2020.1705788$$gp. 1 - 7$$n1$$p9-15$$tExpert review of anticancer therapy$$v20$$x1744-8328$$y2020
000868438 8564_ $$uhttps://juser.fz-juelich.de/record/868438/files/Galldiks_2019_Post%20Print_Expert%20Reviev%20Anticancer%20Ther_Molecular%20imaging%20and%20advanced%20MRI%20findings%20following%20immunotherapy.pdf$$yPublished on 2019-12-23. Available in OpenAccess from 2020-12-23.
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