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024 7 _ |a 10.1080/14737140.2020.1705788
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100 1 _ |a Galldiks, Norbert
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245 _ _ |a Molecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors
260 _ _ |a Abingdon, Oxon
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520 _ _ |a Introduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related changes detected by advanced neuroimaging techniques following the most suitable immunotherapy options currently used in neuro-oncology. We, furthermore, provide an overview of how these advanced imaging techniques may help to overcome shortcomings of standard MRI in the assessment and follow-up of patients with brain cancer.Areas covered: The current literature on neuroimaging for immunotherapy in the field of brain tumors, with a focus on gliomas and brain metastases is summarized.Expert commentary: Data suggest that imaging parameters primarily derived from amino acid PET, diffusion- and perfusion-weighted MRI, or MR spectroscopy are particularly helpful for the evaluation of treatment response and provide valuable information for the differentiation of treatment-induced changes from actual brain tumor progression following various immunotherapy approaches.
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700 1 _ |a Werner, Jan-Michael
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700 1 _ |a Ceccon, Garry
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700 1 _ |a Langen, Karl-Josef
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856 4 _ |y Published on 2019-12-23. Available in OpenAccess from 2020-12-23.
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856 4 _ |y Published on 2019-12-23. Available in OpenAccess from 2020-12-23.
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