000868444 001__ 868444
000868444 005__ 20210130004220.0
000868444 0247_ $$2doi$$a10.1016/j.nicl.2019.102114
000868444 0247_ $$2Handle$$a2128/23785
000868444 0247_ $$2altmetric$$aaltmetric:73283314
000868444 0247_ $$2pmid$$apmid:31884221
000868444 0247_ $$2WOS$$aWOS:000519535200043
000868444 037__ $$aFZJ-2020-00037
000868444 082__ $$a610
000868444 1001_ $$0P:(DE-Juel1)172024$$aCamilleri, Julia A.$$b0
000868444 245__ $$aElectroconvulsive therapy modulates grey matter increase in a hub of an affect processing network
000868444 260__ $$a[Amsterdam u.a.]$$bElsevier$$c2020
000868444 3367_ $$2DRIVER$$aarticle
000868444 3367_ $$2DataCite$$aOutput Types/Journal article
000868444 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1578315774_24844
000868444 3367_ $$2BibTeX$$aARTICLE
000868444 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000868444 3367_ $$00$$2EndNote$$aJournal Article
000868444 520__ $$aA growing number of recent studies has suggested that the neuroplastic effects of electroconvulsive therapy (ECT) might be prominent enough to be detected through changes of regional gray matter volumes (GMV) during the course of the treatment. Given that ECT patients are difficult to recruit for imaging studies, most publications, however, report only on small samples. Addressing this challenge, we here report results of a structural imaging study on ECT patients that pooled patients from five German sites. Whole-brain voxel-based morphometry (VBM) analysis was performed to detect structural differences in 85 patients with unipolar depression before and after ECT, when compared to 86 healthy controls. Both task-independent and task-dependent physiological whole-brain functional connectivity patterns of these regions were modeled using additional data from healthy subjects. All emerging regions were additionally functionally characterized using the BrainMap database. Our VBM analysis detected a significant increase of GMV in the right hippocampus/amygdala region in patients after ECT compared to healthy controls. In healthy subjects this region was found to be enrolled in a network associated with emotional processing and memory. A region in the left fusiform gyrus was additionally found to have higher GMV in controls when compared with patients at baseline. This region showed minor changes after ECT. Our data points to a GMV increase in patients post ECT in regions that seem to constitute a hub of an emotion processing network. This appears as a plausible antidepressant mechanism and could explain the efficacy of ECT not only in the treatment of unipolar depression, but also of affective symptoms across heterogeneous disorders.
000868444 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000868444 588__ $$aDataset connected to CrossRef
000868444 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b1
000868444 7001_ $$0P:(DE-HGF)0$$aZavorotny, Maxim$$b2
000868444 7001_ $$0P:(DE-HGF)0$$aZöllner, Rebecca$$b3
000868444 7001_ $$00000-0002-5358-5212$$aWolf, Robert Christian$$b4
000868444 7001_ $$0P:(DE-HGF)0$$aThomann, Philipp$$b5
000868444 7001_ $$0P:(DE-HGF)0$$aRedlich, Ronny$$b6
000868444 7001_ $$0P:(DE-HGF)0$$aOpel, Nils$$b7
000868444 7001_ $$0P:(DE-HGF)0$$aDannlowski, Udo$$b8
000868444 7001_ $$0P:(DE-HGF)0$$aGroezinger, Michael$$b9
000868444 7001_ $$0P:(DE-HGF)0$$aDemirakca, Traute$$b10
000868444 7001_ $$0P:(DE-HGF)0$$aSartorius, Alexander$$b11
000868444 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b12
000868444 7001_ $$00000-0003-2616-6503$$aNickl-Jockschat, Thomas$$b13$$eCorresponding author
000868444 773__ $$0PERI:(DE-600)2701571-3$$a10.1016/j.nicl.2019.102114$$gVol. 25, p. 102114 -$$p102114 -$$tNeuroImage: Clinical$$v25$$x2213-1582$$y2020
000868444 8564_ $$uhttps://juser.fz-juelich.de/record/868444/files/Camilleri20.pdf$$yOpenAccess
000868444 8564_ $$uhttps://juser.fz-juelich.de/record/868444/files/ECT%20paper%20final%20version%20Camilleri20.pdf$$yOpenAccess
000868444 8564_ $$uhttps://juser.fz-juelich.de/record/868444/files/Camilleri20.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000868444 8564_ $$uhttps://juser.fz-juelich.de/record/868444/files/ECT%20paper%20final%20version%20Camilleri20.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000868444 909CO $$ooai:juser.fz-juelich.de:868444$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000868444 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)172024$$aForschungszentrum Jülich$$b0$$kFZJ
000868444 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131684$$aForschungszentrum Jülich$$b1$$kFZJ
000868444 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b12$$kFZJ
000868444 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000868444 9141_ $$y2020
000868444 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000868444 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000868444 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROIMAGE-CLIN : 2017
000868444 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000868444 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000868444 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000868444 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000868444 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000868444 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000868444 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review
000868444 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000868444 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000868444 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000868444 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000868444 920__ $$lyes
000868444 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
000868444 980__ $$ajournal
000868444 980__ $$aVDB
000868444 980__ $$aUNRESTRICTED
000868444 980__ $$aI:(DE-Juel1)INM-7-20090406
000868444 9801_ $$aFullTexts