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@ARTICLE{Camilleri:868444,
      author       = {Camilleri, Julia A. and Hoffstaedter, Felix and Zavorotny,
                      Maxim and Zöllner, Rebecca and Wolf, Robert Christian and
                      Thomann, Philipp and Redlich, Ronny and Opel, Nils and
                      Dannlowski, Udo and Groezinger, Michael and Demirakca,
                      Traute and Sartorius, Alexander and Eickhoff, Simon B. and
                      Nickl-Jockschat, Thomas},
      title        = {{E}lectroconvulsive therapy modulates grey matter increase
                      in a hub of an affect processing network},
      journal      = {NeuroImage: Clinical},
      volume       = {25},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-00037},
      pages        = {102114 -},
      year         = {2020},
      abstract     = {A growing number of recent studies has suggested that the
                      neuroplastic effects of electroconvulsive therapy (ECT)
                      might be prominent enough to be detected through changes of
                      regional gray matter volumes (GMV) during the course of the
                      treatment. Given that ECT patients are difficult to recruit
                      for imaging studies, most publications, however, report only
                      on small samples. Addressing this challenge, we here report
                      results of a structural imaging study on ECT patients that
                      pooled patients from five German sites. Whole-brain
                      voxel-based morphometry (VBM) analysis was performed to
                      detect structural differences in 85 patients with unipolar
                      depression before and after ECT, when compared to 86 healthy
                      controls. Both task-independent and task-dependent
                      physiological whole-brain functional connectivity patterns
                      of these regions were modeled using additional data from
                      healthy subjects. All emerging regions were additionally
                      functionally characterized using the BrainMap database. Our
                      VBM analysis detected a significant increase of GMV in the
                      right hippocampus/amygdala region in patients after ECT
                      compared to healthy controls. In healthy subjects this
                      region was found to be enrolled in a network associated with
                      emotional processing and memory. A region in the left
                      fusiform gyrus was additionally found to have higher GMV in
                      controls when compared with patients at baseline. This
                      region showed minor changes after ECT. Our data points to a
                      GMV increase in patients post ECT in regions that seem to
                      constitute a hub of an emotion processing network. This
                      appears as a plausible antidepressant mechanism and could
                      explain the efficacy of ECT not only in the treatment of
                      unipolar depression, but also of affective symptoms across
                      heterogeneous disorders.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31884221},
      UT           = {WOS:000519535200043},
      doi          = {10.1016/j.nicl.2019.102114},
      url          = {https://juser.fz-juelich.de/record/868444},
}