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000008722 084__ $$2WoS$$aPhysics, Multidisciplinary
000008722 1001_ $$0P:(DE-Juel1)VDB37578$$aNoguchi, H.$$b0$$uFZJ
000008722 245__ $$aDynamics of fluid vesicles in flow through structured microchannels
000008722 260__ $$aLes Ulis$$bEDP Sciences$$c2010
000008722 300__ $$a28002
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000008722 440_0 $$01996$$aEurophysics Letters$$v89$$x0295-5075
000008722 500__ $$aWe acknowledge support of this work through the DFG priority program "Nano- and Microfluidics" (SPP 1164) and the "Nanosystems Initiative Munich" (NIM).
000008722 520__ $$aThe dynamics of fluid vesicles is studied under flow in microchannels, in which the width varies periodically along the channel. Three types of flow instabilities of prolate vesicles are found. For small quasi-spherical vesicles-compared to the average channel width perturbation theory predicts a transition from a state with orientational oscillations of a fixed prolate shape to a state with shape oscillations of symmetrical ellipsoidal or bullet-like shapes with increasing. flow velocity. Experimentally, such orientational oscillations are observed during the slow migration of a vesicle towards the centerline of the channel. For larger vesicles, mesoscale hydrodynamics simulations and experiments show similar symmetric shape oscillation at reduced volumes V* greater than or similar to 0.9. However, for non-spherical vesicles with V* less than or similar to 0.9, shapes are found with two symmetric or a single asymmetric tail. Copyright (C) EPLA, 2010
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