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@ARTICLE{Farrher:872626,
      author       = {Farrher, Ezequiel and Grinberg, Farida and Kuo, Li‐Wei
                      and Cho, Kuan‐Hung and Buschbeck, Richard P. and Chen,
                      Ming‐Jye and Chiang, Husan‐Han and Choi, Chang‐Hoon
                      and Shah, N. J.},
      title        = {{D}edicated diffusion phantoms for the investigation of
                      free water elimination and mapping: insights into the
                      influence of {T} 2 relaxation properties},
      journal      = {NMR in biomedicine},
      volume       = {33},
      number       = {4},
      issn         = {1099-1492},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2020-00118},
      pages        = {e4210},
      year         = {2020},
      abstract     = {Conventional diffusion‐weighted (DW) MRI suffers from
                      free water contamination due to the finite voxel size. The
                      most common case of free water contamination occurs with
                      cerebrospinal fluid (CSF) in voxels located at the
                      CSF‐tissue interface, such as at the ventricles in the
                      human brain. Another case refers to intra‐tissue free
                      water as in vasogenic oedema. In order to avoid the bias in
                      diffusion metrics, several multi‐compartment methods have
                      been introduced, which explicitly model the presence of a
                      free water compartment. However, fitting multi‐compartment
                      models in DW MRI represents a well known ill conditioned
                      problem. Although during the last decade great effort has
                      been devoted to mitigating this estimation problem, the
                      research field remains active.The aim of this work is to
                      introduce the design, characterise the NMR properties and
                      demonstrate the use of two dedicated anisotropic diffusion
                      fibre phantoms, useful for the study of free water
                      elimination (FWE) and mapping models. In particular, we
                      investigate the recently proposed FWE diffusion tensor
                      imaging approach, which takes explicit account of
                      differences in the transverse relaxation times between the
                      free water and tissue compartments.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31926122},
      UT           = {WOS:000506553100001},
      doi          = {10.1002/nbm.4210},
      url          = {https://juser.fz-juelich.de/record/872626},
}