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| Hauptseite > Publikationsdatenbank > Flare phenomenon in O-(2-[ 18 F]-Fluoroethyl)-L-Tyrosine PET after resection of gliomas > print |
| Hauptseite > Publikationsdatenbank > Flare phenomenon in O-(2-[ 18 F]-Fluoroethyl)-L-Tyrosine PET after resection of gliomas > print |
| 001 | 872736 | ||
| 005 | 20220930130227.0 | ||
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| 100 | 1 | _ | |a Filss, Christian P |0 P:(DE-Juel1)141877 |b 0 |u fzj |
| 245 | _ | _ | |a Flare phenomenon in O-(2-[ 18 F]-Fluoroethyl)-L-Tyrosine PET after resection of gliomas |
| 260 | _ | _ | |a New York, NY |c 2020 |b Soc. |
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| 520 | _ | _ | |a PET using O-(2-[18F]Fluoroethyl)-L-tyrosine (18F-FET) is useful to detect residual tumor tissue after glioma resection. Recent animal experiments detected reactive changes of 18F-FET uptake at the rim of the resection cavity within the first two weeks after resection of gliomas. In the present study, we evaluated pre- and postoperative 18F-FET PET scans of glioma patients with particular emphasis on the identification of reactive changes after surgery. Methods: Forty-three patients with cerebral gliomas (9 low-grade, 34 high-grade; 9 primary tumors, 34 recurrent tumors) who had preoperative (time before surgery, median 23 d, range 6-44 d) and postoperative 18F-FET-PET (time after surgery, median 14, range 5–28 d) were included. PET scans (20-40 min p.i.) were evaluated visually for complete or incomplete resection (CR, IR) and compared with MRI. Changes of 18F-FET-uptake in residual tumor were evaluated by tumor-to-brain ratios (TBRmax) and in the vicinity of the resection cavity by maximum lesion-to-brain ratios (LBRmax). Results: Visual analysis of 18F-FET PET scans revealed CR in 16/43 patients and IR in the remaining patients. PET results were concordant with MRI in 69% of the patients. LBRmax of 18F-FET uptake in the vicinity of the resection cavity was significantly higher compared with preoperative values (1.59 ± 0.36 versus 1.14 ± 0.17; n = 43, p<0.001). In 11 patients (26%) a “flare phenomenon” was observed with a considerable increase of 18F-FET uptake compared with preoperative values in either the residual tumor (n = 5) or in areas remote from tumor in the preoperative PET scan (n = 6) (2.92 ± 1.24 versus 1.62 ± 0.75; p<0.001). Further follow-up in five patients showed decreasing 18F-FET uptake in the flare areas in four and progress in one case. Conclusion: Our study confirms that 18F-FET PET provides valuable information for assessing the success of glioma resection. Postoperative reactive changes at the rim of the resection cavity appear to be mild. However, in 23 % of the patients, a postoperative “flare phenomenon” was observed that warrants further investigation. |
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| 773 | _ | _ | |a 10.2967/jnumed.119.238568 |g p. jnumed.119.238568 - |0 PERI:(DE-600)2040222-3 |n 9 |p 1294-1299 |t Journal of nuclear medicine |v 61 |y 2020 |x 0022-3123 |
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