guest ::
| Home > Publications database > Smad7 in intestinal CD4 + T cells determines autoimmunity in a spontaneous model of multiple sclerosis > print |
| Home > Publications database > Smad7 in intestinal CD4 + T cells determines autoimmunity in a spontaneous model of multiple sclerosis > print |
| 001 | 872748 | ||
| 005 | 20210130004259.0 | ||
| 024 | 7 | _ | |a 10.1073/pnas.1905955116 |2 doi |
| 024 | 7 | _ | |a 0027-8424 |2 ISSN |
| 024 | 7 | _ | |a 1091-6490 |2 ISSN |
| 024 | 7 | _ | |a 2128/23873 |2 Handle |
| 024 | 7 | _ | |a altmetric:71954679 |2 altmetric |
| 024 | 7 | _ | |a pmid:31796589 |2 pmid |
| 024 | 7 | _ | |a WOS:000503281500070 |2 WOS |
| 037 | _ | _ | |a FZJ-2020-00226 |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Haupeltshofer, Steffen |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Smad7 in intestinal CD4 + T cells determines autoimmunity in a spontaneous model of multiple sclerosis |
| 260 | _ | _ | |a Washington, DC |c 2019 |b National Acad. of Sciences |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1579101412_8097 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Environmental triggers acting at the intestinal barrier are thought to contribute to the initiation of autoimmune disorders. The transforming growth factor beta inhibitor Smad7 determines the phenotype of CD4+ T cells. We hypothesized that Smad7 in intestinal CD4+ T cells controls initiation of opticospinal encephalomyelitis (OSE), a murine model of multiple sclerosis (MS), depending on the presence of gut microbiota. Smad7 was overexpressed or deleted in OSE CD4+ T cells to determine the effect on clinical progression, T cell differentiation, and T cell migration from the intestine to the central nervous system (CNS). Smad7 overexpression worsened the clinical course of OSE and increased CNS inflammation and demyelination. It favored expansion of intestinal CD4+ T cells toward an inflammatory phenotype and migration of intestinal CD4+ T cells to the CNS. Intestinal biopsies from MS patients revealed decreased transforming growth factor beta signaling with a shift toward inflammatory T cell subtypes. Smad7 in intestinal T cells might represent a valuable therapeutic target for MS to achieve immunologic tolerance in the intestine and suppress CNS inflammation. |
| 536 | _ | _ | |a 553 - Physical Basis of Diseases (POF3-553) |0 G:(DE-HGF)POF3-553 |c POF3-553 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a Leichsenring, Teresa |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Berg, Sarah |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Pedreiturria, Xiomara |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Joachim, Stephanie C. |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Tischoff, Iris |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Otte, Jan-Michel |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Bopp, Tobias |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Fantini, Massimo C. |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Esser, Charlotte |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Willbold, Dieter |0 P:(DE-Juel1)132029 |b 10 |u fzj |
| 700 | 1 | _ | |a Gold, Ralf |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Faissner, Simon |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Kleiter, Ingo |0 0000-0002-8249-4408 |b 13 |e Corresponding author |
| 773 | _ | _ | |a 10.1073/pnas.1905955116 |g Vol. 116, no. 51, p. 25860 - 25869 |0 PERI:(DE-600)1461794-8 |n 51 |p 25860 - 25869 |t Proceedings of the National Academy of Sciences of the United States of America |v 116 |y 2019 |x 1091-6490 |
| 856 | 4 | _ | |y Published on 2019-12-03. Available in OpenAccess from 2020-06-03. |u https://juser.fz-juelich.de/record/872748/files/Smad7%20in%20intestinal%20CD4%2B%20T%20cells%20determines%20autoimmunity%20in%20a%20spontaneous%20model%20of%20multiple%20sclerosis.pdf |
| 856 | 4 | _ | |y Published on 2019-12-03. Available in OpenAccess from 2020-06-03. |x pdfa |u https://juser.fz-juelich.de/record/872748/files/Smad7%20in%20intestinal%20CD4%2B%20T%20cells%20determines%20autoimmunity%20in%20a%20spontaneous%20model%20of%20multiple%20sclerosis.pdf?subformat=pdfa |
| 909 | C | O | |o oai:juser.fz-juelich.de:872748 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 10 |6 P:(DE-Juel1)132029 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences |1 G:(DE-HGF)POF3-550 |0 G:(DE-HGF)POF3-553 |2 G:(DE-HGF)POF3-500 |v Physical Basis of Diseases |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2019 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a Embargoed OpenAccess |0 StatID:(DE-HGF)0530 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b P NATL ACAD SCI USA : 2017 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b P NATL ACAD SCI USA : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a National-Konsortium |0 StatID:(DE-HGF)0430 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)ICS-6-20110106 |k ICS-6 |l Strukturbiochemie |x 0 |
| 980 | 1 | _ | |a FullTexts |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-6-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-7-20200312 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|