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| Home > Publications database > Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents > print |
| Home > Publications database > Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents > print |
| 001 | 872752 | ||
| 005 | 20210130004300.0 | ||
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| 245 | _ | _ | |a Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents |
| 260 | _ | _ | |a Lawrence, Kan. |c 2019 |b PLoS |
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| 520 | _ | _ | |a Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and contribute to biofilm formation, thereby promoting bacterial resistance to environmental stressors. Here, we present crystal structures of amyloid-forming segments from the major curli subunit, CsgA, revealing steric zipper fibrils of tightly mated β-sheets, demonstrating a structural link between curli and human pathological amyloids. D-enantiomeric peptides, originally developed to interfere with Alzheimer's disease-associated amyloid-β, inhibited CsgA fibrillation and reduced biofilm formation in Salmonella typhimurium. Moreover, as previously shown, CsgA fibrils cross-seeded fibrillation of amyloid-β, providing support for the proposed structural resemblance and potential for cross-species amyloid interactions. The presented findings provide structural insights into amyloidogenic regions important for curli formation, suggest a novel strategy for disrupting amyloid-structured biofilms, and hypothesize on the formation of self-propagating prion-like species originating from a microbial source that could influence neurodegenerative diseases |
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| 700 | 1 | _ | |a Deshmukh, Maya |0 0000-0002-3704-3229 |b 5 |
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| 700 | 1 | _ | |a Landau, Meytal |0 0000-0002-1743-3430 |b 7 |e Corresponding author |
| 773 | _ | _ | |a 10.1371/journal.ppat.1007978 |g Vol. 15, no. 8, p. e1007978 - |0 PERI:(DE-600)2205412-1 |n 8 |p e1007978 - |t PLoS pathogens |v 15 |y 2019 |x 1553-7374 |
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