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000872946 1001_ $$0P:(DE-HGF)0$$aXu, Anna$$b0
000872946 245__ $$aConvergent neural representations of experimentally-induced acute pain in healthy volunteers: A large-scale fMRI meta-analysis
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000872946 520__ $$aCharacterizing a reliable, pain-related neural signature is critical for translational applications. Many prior fMRI studies have examined acute nociceptive pain-related brain activation in healthy participants. However, synthesizing these data to identify convergent patterns of activation can be challenging due to the heterogeneity of experimental designs and samples. To address this challenge, we conducted a comprehensive meta-analysis of fMRI studies of stimulus-induced pain in healthy participants. Following pre-registration, two independent reviewers evaluated 4,927 abstracts returned from a search of 8 databases, with 222 fMRI experiments meeting inclusion criteria. We analyzed these experiments using Activation Likelihood Estimation with rigorous type I error control (voxel height p < 0.001, cluster p < 0.05 FWE-corrected) and found a convergent, largely bilateral pattern of pain-related activation in the secondary somatosensory cortex, insula, midcingulate cortex, and thalamus. Notably, these regions were consistently recruited regardless of stimulation technique, location of induction, and participant sex. These findings suggest a highly-conserved core set of pain-related brain areas, encouraging applications as a biomarker for novel therapeutics targeting acute nociceptive pain.
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000872946 7001_ $$0P:(DE-HGF)0$$aLarsen, Bart$$b1
000872946 7001_ $$0P:(DE-HGF)0$$aBaller, Erica B.$$b2
000872946 7001_ $$0P:(DE-HGF)0$$aCobb Scott, J.$$b3
000872946 7001_ $$0P:(DE-HGF)0$$aSharma, Vaishnavi$$b4
000872946 7001_ $$0P:(DE-HGF)0$$aAdebimpe, Azeez$$b5
000872946 7001_ $$0P:(DE-HGF)0$$aBasbaum, Allan I.$$b6
000872946 7001_ $$0P:(DE-HGF)0$$aDworkin, Robert H.$$b7
000872946 7001_ $$0P:(DE-HGF)0$$aEdwards, Robert R.$$b8
000872946 7001_ $$0P:(DE-HGF)0$$aWoolf, Clifford J.$$b9
000872946 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b10
000872946 7001_ $$0P:(DE-Juel1)174483$$aEickhoff, Claudia R.$$b11
000872946 7001_ $$0P:(DE-HGF)0$$aSatterthwaite, Theodore D.$$b12$$eCorresponding author
000872946 773__ $$0PERI:(DE-600)1498433-7$$a10.1016/j.neubiorev.2020.01.004$$gp. S0149763419308656$$p300-323$$tNeuroscience & biobehavioral reviews$$v112$$x0149-7634$$y2020
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