TY  - JOUR
AU  - Xu, Anna
AU  - Larsen, Bart
AU  - Baller, Erica B.
AU  - Cobb Scott, J.
AU  - Sharma, Vaishnavi
AU  - Adebimpe, Azeez
AU  - Basbaum, Allan I.
AU  - Dworkin, Robert H.
AU  - Edwards, Robert R.
AU  - Woolf, Clifford J.
AU  - Eickhoff, Simon B.
AU  - Eickhoff, Claudia R.
AU  - Satterthwaite, Theodore D.
TI  - Convergent neural representations of experimentally-induced acute pain in healthy volunteers: A large-scale fMRI meta-analysis
JO  - Neuroscience & biobehavioral reviews
VL  - 112
SN  - 0149-7634
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2020-00406
SP  - 300-323
PY  - 2020
AB  - Characterizing a reliable, pain-related neural signature is critical for translational applications. Many prior fMRI studies have examined acute nociceptive pain-related brain activation in healthy participants. However, synthesizing these data to identify convergent patterns of activation can be challenging due to the heterogeneity of experimental designs and samples. To address this challenge, we conducted a comprehensive meta-analysis of fMRI studies of stimulus-induced pain in healthy participants. Following pre-registration, two independent reviewers evaluated 4,927 abstracts returned from a search of 8 databases, with 222 fMRI experiments meeting inclusion criteria. We analyzed these experiments using Activation Likelihood Estimation with rigorous type I error control (voxel height p < 0.001, cluster p < 0.05 FWE-corrected) and found a convergent, largely bilateral pattern of pain-related activation in the secondary somatosensory cortex, insula, midcingulate cortex, and thalamus. Notably, these regions were consistently recruited regardless of stimulation technique, location of induction, and participant sex. These findings suggest a highly-conserved core set of pain-related brain areas, encouraging applications as a biomarker for novel therapeutics targeting acute nociceptive pain.
LB  - PUB:(DE-HGF)16
C6  - pmid:31954149
UR  - <Go to ISI:>//WOS:000531016100019
DO  - DOI:10.1016/j.neubiorev.2020.01.004
UR  - https://juser.fz-juelich.de/record/872946
ER  -