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@ARTICLE{Hohenfeld:873055,
      author       = {Hohenfeld, Christian and Kuhn, Hanna and Müller, Christine
                      and Nellessen, Nils and Ketteler, Simon and Heinecke, Armin
                      and Goebel, Rainer and Shah, N. Jon and Schulz, Jörg B. and
                      Reske, Martina and Reetz, Kathrin},
      title        = {{C}hanges in brain activation related to visuo-spatial
                      memory after real-time f{MRI} neurofeedback training in
                      healthy elderly and {A}lzheimer’s disease},
      journal      = {Behavioural brain research},
      volume       = {381},
      issn         = {0166-4328},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-00504},
      pages        = {112435 -},
      year         = {2020},
      abstract     = {Cognitive decline is a symptom of healthy ageing and
                      Alzheimer’s disease. We examined the effect of real-time
                      fMRI based neurofeedback training on visuo-spatial memory
                      and its associated neuronal response.Twelve healthy subjects
                      and nine patients of prodromal Alzheimer’s disease were
                      included. The examination spanned five days (T1–T5): T1
                      contained a neuropsychological pre-test, the encoding of an
                      itinerary and a fMRI-based task related that itinerary.
                      T2–T4 hosted the real-time fMRI neurofeedback training of
                      the parahippocampal gyrus and on T5 a post-test session
                      including encoding of another itinerary and a subsequent
                      fMRI-based task were done. Scores from neuropsychological
                      tests, brain activation and task performance during the
                      fMRI-paradigm were compared between pre and post-test as
                      well as between healthy controls and patients.Behavioural
                      performance in the fMRI-task remained unchanged, while
                      cognitive testing showed improvements in visuo-spatial
                      memory performance. Both groups displayed task-relevant
                      brain activation, which decreased in the right precentral
                      gyrus and left occipital lobe from pre to post-test in
                      controls, but increased in the right occipital lobe, middle
                      frontal gyrus and left frontal lobe in the patient
                      group.While results suggest that the training has affected
                      brain activation differently between controls and patients,
                      there are no pointers towards a behavioural manifestation of
                      these changes. Future research is required on the effects
                      that can be induced using real-time fMRI based neurofeedback
                      training and the required training duration to elicit broad
                      and lasting effects.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31863845},
      UT           = {WOS:000526063100024},
      doi          = {10.1016/j.bbr.2019.112435},
      url          = {https://juser.fz-juelich.de/record/873055},
}