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@ARTICLE{PalomeroGallagher:873406,
      author       = {Palomero-Gallagher, Nicola and Kedo, Olga and Mohlberg,
                      Hartmut and Zilles, Karl and Amunts, Katrin},
      title        = {{M}ultimodal mapping and analysis of the cyto- and
                      receptorarchitecture of the human hippocampus},
      journal      = {Brain structure $\&$ function},
      volume       = {225},
      issn         = {1863-2661},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {FZJ-2020-00716},
      pages        = {881–907},
      year         = {2020},
      abstract     = {The human hippocampal formation is relevant for various
                      aspects of memory and learning, and the different
                      hippocampal regions are differentially affected by
                      neuropsychiatric disorders. Therefore, the hippocampal
                      formation has been subject of numerous cytoarchitectonic and
                      other mapping studies, which resulted in divergent
                      parcellation schemes. To understand the principles of
                      hippocampal architecture, it is necessary to integrate
                      different levels of hippocampal organisation, going beyond
                      one modality. We here applied a multimodal mapping approach
                      combining cyto- and multi-receptorarchitectonic analyses,
                      and generated probabilistic maps in stereotaxic space of the
                      identified regions. Cytoarchitecture in combination with the
                      regional and laminar distribution of 15 neurotransmitter
                      receptors visualized by in vitro receptor autoradiography
                      were analysed in seven hemispheres from 6 unfixed shock
                      frozen and serially sectioned brains. Cytoarchitectonic
                      delineations for generation of probabilistic maps were
                      carried out on histological sections from ten fixed,
                      paraffin embedded and serially sectioned brains. Nine cyto-
                      and receptorarchitectonically distinct regions were
                      identified within the hippocampal formation (i.e., fascia
                      dentata, cornu Ammonis (CA) regions 1–4, prosubiculum,
                      subiculum proper, presubiculum and parasubiculum), as well
                      as the hippocampal-amygdaloid transition area and the
                      periallocortical transsubiculum. Subsequently generated
                      probabilistic maps quantify intersubject variability in the
                      size and extent of these cyto- and receptorarchitectonically
                      distinct regions. The regions did not differ in their volume
                      between the hemispheres and gender. Receptor mapping
                      revealed additional subdivisions which could not be detected
                      by cytoarchitectonic analysis alone. They correspond to
                      parcellations previously found in immunohistochemical and
                      connectivity studies. The multimodal approach enabled the
                      definition of regions not consistently reported, e.g., CA4
                      region or prosubiculum. The ensuing detailed probabilistic
                      maps of the hippocampal formation constitute the basis for
                      future architectonically informed analyses of in vivo
                      neuroimaging studies.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / HBP SGA2 -
                      Human Brain Project Specific Grant Agreement 2 (785907)},
      pid          = {G:(DE-HGF)POF3-571 / G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31955294},
      UT           = {WOS:000517230500001},
      doi          = {10.1007/s00429-019-02022-4},
      url          = {https://juser.fz-juelich.de/record/873406},
}