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000873521 1001_ $$0P:(DE-HGF)0$$aBecker, Johannes$$b0
000873521 245__ $$aThe effects of thalamic and posterior subthalamic deep brain stimulation on speech in patients with essential tremor – A prospective, randomized, doubleblind crossover study
000873521 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2020
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000873521 520__ $$aObjectiveTo prospectively evaluate the effect of PSA- and VIM DBS on speech in ET patients.MethodsLeads were implanted bilaterally with contacts placed in both VIM and PSA. Thirteen patients were analyzed pre- and postoperatively. Preoperative speech of ET patients was compared to healthy controls. PSA- and VIM-DBS were evaluated in a randomized, double-blind crossover phase.ResultsAt preoperative baseline, we found reduced intelligibility. Differences in acoustic and VAS data (‘ability to speak’) compared to controls were gradient. Articulation rate could be predicted by disease duration. Decreased articulation rate, spirantization and voicing were found for PSA- and VIM-DBS. Targets did not differ in terms of speech deterioration.ConclusionSpeech in ET patients without DBS can be impaired, dependent on patient’s individual characteristics. Both PSA- and VIM-DBS affect speech in a comparable way. Thus, the PSA can be considered an alternative DBS target in ET without higher risk of dysarthria.
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000873521 7001_ $$00000-0001-9149-3143$$aThies, Tabea$$b1
000873521 7001_ $$0P:(DE-HGF)0$$aPetry-Schmelzer, Jan Niklas$$b2
000873521 7001_ $$0P:(DE-HGF)0$$aDembek, Till A.$$b3
000873521 7001_ $$00000-0003-4590-708X$$aReker, Paul$$b4
000873521 7001_ $$0P:(DE-HGF)0$$aMücke, Doris$$b5
000873521 7001_ $$0P:(DE-HGF)0$$aGrice, Martine$$b6
000873521 7001_ $$0P:(DE-HGF)0$$aVisser-Vandewalle, Veerle$$b7
000873521 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b8
000873521 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael$$b9$$eCorresponding author
000873521 773__ $$0PERI:(DE-600)1462477-1$$a10.1016/j.bandl.2019.104724$$gVol. 202, p. 104724 -$$p104724 -$$tBrain and language$$v202$$x0093-934X$$y2020
000873521 8564_ $$uhttps://juser.fz-juelich.de/record/873521/files/Becker_2019_Post%20Print_Brain%20%26%20Language_The%20effects%20of%20thalamic%20and%20posterior%20subthalamic%20deep%20brain%20stimulation.pdf$$yPublished on 2019-12-26. Available in OpenAccess from 2020-12-26.
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