TY  - JOUR
AU  - Becker, Johannes
AU  - Thies, Tabea
AU  - Petry-Schmelzer, Jan Niklas
AU  - Dembek, Till A.
AU  - Reker, Paul
AU  - Mücke, Doris
AU  - Grice, Martine
AU  - Visser-Vandewalle, Veerle
AU  - Fink, Gereon R.
AU  - Barbe, Michael
TI  - The effects of thalamic and posterior subthalamic deep brain stimulation on speech in patients with essential tremor – A prospective, randomized, doubleblind crossover study
JO  - Brain and language
VL  - 202
SN  - 0093-934X
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - FZJ-2020-00789
SP  - 104724 -
PY  - 2020
AB  - ObjectiveTo prospectively evaluate the effect of PSA- and VIM DBS on speech in ET patients.MethodsLeads were implanted bilaterally with contacts placed in both VIM and PSA. Thirteen patients were analyzed pre- and postoperatively. Preoperative speech of ET patients was compared to healthy controls. PSA- and VIM-DBS were evaluated in a randomized, double-blind crossover phase.ResultsAt preoperative baseline, we found reduced intelligibility. Differences in acoustic and VAS data (‘ability to speak’) compared to controls were gradient. Articulation rate could be predicted by disease duration. Decreased articulation rate, spirantization and voicing were found for PSA- and VIM-DBS. Targets did not differ in terms of speech deterioration.ConclusionSpeech in ET patients without DBS can be impaired, dependent on patient’s individual characteristics. Both PSA- and VIM-DBS affect speech in a comparable way. Thus, the PSA can be considered an alternative DBS target in ET without higher risk of dysarthria.
LB  - PUB:(DE-HGF)16
C6  - pmid:31884313
UR  - <Go to ISI:>//WOS:000514220400001
DO  - DOI:10.1016/j.bandl.2019.104724
UR  - https://juser.fz-juelich.de/record/873521
ER  -