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@ARTICLE{Coleman:873593,
author = {Coleman, Jonathan R. I. and Gaspar, Héléna A. and Bryois,
Julien and Breen, Gerome and Byrne, Enda M. and Forstner,
Andreas J. and Holmans, Peter A. and de Leeuw, Christiaan A.
and Mattheisen, Manuel and McQuillin, Andrew and Whitehead
Pavlides, Jennifer M. and Pers, Tune H. and Ripke, Stephan
and Stahl, Eli A. and Steinberg, Stacy and Trubetskoy,
Vassily and Trzaskowski, Maciej and Wang, Yunpeng and
Abbott, Liam and Abdellaoui, Abdel and Adams, Mark J. and
Adolfsson, Annelie Nordin and Agerbo, Esben and Akil, Huda
and Albani, Diego and Alliey-Rodriguez, Ney and Als, Thomas
D. and Andlauer, Till F. M. and Anjorin, Adebayo and
Antilla, Verneri and Van der Auwera, Sandra and Awasthi,
Swapnil and Bacanu, Silviu-Alin and Badner, Judith A. and
Bækvad-Hansen, Marie and Barchas, Jack D. and Bass,
Nicholas and Bauer, Michael and Beekman, Aartjan T. F. and
Belliveau, Richard and Bergen, Sarah E. and Bigdeli, Tim B.
and Binder, Elisabeth B. and Bøen, Erlend and Boks, Marco
and Boocock, James and Budde, Monika and Bunney, William and
Burmeister, Margit and Buttenschøn, Henriette N. and
Bybjerg-Grauholm, Jonas and Byerley, William and Cai, Na and
Casas, Miquel and Castelao, Enrique and Cerrato, Felecia and
Cervantes, Pablo and Chambert, Kimberly and Charney,
Alexander W. and Chen, Danfeng and Christensen, Jane
Hvarregaard and Churchhouse, Claire and St Clair, David and
Clarke, Toni-Kim and Colodro-Conde, Lucía and Coryell,
William and Couvy-Duchesne, Baptiste and Craig, David W. and
Crawford, Gregory E. and Cruceanu, Cristiana and Czerski,
Piotr M. and Dale, Anders M. and Davies, Gail and Deary, Ian
J. and Degenhardt, Franziska and Del-Favero, Jurgen and
DePaulo, J Raymond and Derks, Eske M. and Direk, Nese and
Djurovic, Srdjan and Dobbyn, Amanda L. and Dolan, Conor V.
and Dumont, Ashley and Dunn, Erin C. and Eley, Thalia C. and
Elvsåshagen, Torbjørn and Escott-Price, Valentina and Fan,
Chun Chieh and Finucane, Hilary K. and Fischer, Sascha B.
and Flickinger, Matthew and Foo, Jerome C. and Foroud,
Tatiana M. and Forty, Liz and Frank, Josef and Fraser,
Christine and Freimer, Nelson B. and Frisén, Louise and
Gade, Katrin and Gage, Diane and Garnham, Julie and
Giambartolomei, Claudia and Goes, Fernando S. and Goldstein,
Jaqueline and Gordon, Scott D. and Gordon-Smith, Katherine
and Green, Elaine K. and Green, Melissa J. and Greenwood,
Tiffany A. and Grove, Jakob and Guan, Weihua and Hall,
Lynsey S. and Hamshere, Marian L. and Hansen, Christine
Søholm and Hansen, Thomas F. and Hautzinger, Martin and
Heilbronner, Urs and van Hemert, Albert M. and Herms, Stefan
and Hickie, Ian B. and Hipolito, Maria and Hoffmann, Per and
Holland, Dominic and Homuth, Georg and Horn, Carsten and
Hottenga, Jouke-Jan and Huckins, Laura and Ising, Marcus and
Jamain, Stéphane and Jansen, Rick and Johnson, Jessica S.
and de Jong, Simone and Jorgenson, Eric and Juréus, Anders
and Kandaswamy, Radhika and Karlsson, Robert and Kennedy,
James L. and Hassan Kiadeh, Farnush Farhadi and
Kittel-Schneider, Sarah and Knowles, James A. and Kogevinas,
Manolis and Kohane, Isaac S. and Koller, Anna C. and Kraft,
Julia and Kretzschmar, Warren W. and Krogh, Jesper and
Kupka, Ralph and Kutalik, Zoltán and Lavebratt, Catharina
and Lawrence, Jacob and Lawson, William B. and Leber, Markus
and Lee, Phil H. and Levy, Shawn E. and Li, Jun Z. and Li,
Yihan and Lind, Penelope A. and Liu, Chunyu and Olde
Loohuis, Loes M. and Maaser, Anna and MacIntyre, Donald J.
and MacKinnon, Dean F. and Mahon, Pamela B. and Maier,
Wolfgang and Maier, Robert M. and Marchini, Jonathan and
Martinsson, Lina and Mbarek, Hamdi and McCarroll, Steve and
McGrath, Patrick and McGuffin, Peter and McInnis, Melvin G.
and McKay, James D. and Medeiros, Helena and Medland, Sarah
E. and Mehta, Divya and Meng, Fan and Middeldorp, Christel
M. and Mihailov, Evelin and Milaneschi, Yuri and Milani,
Lili and Mirza, Saira Saeed and Mondimore, Francis M. and
Montgomery, Grant W. and Morris, Derek W. and Mostafavi,
Sara and Mühleisen, Thomas W. and Mullins, Niamh and Nauck,
Matthias and Ng, Bernard and Nguyen, Hoang and Nievergelt,
Caroline M. and Nivard, Michel G. and Nwulia, Evaristus A.
and Nyholt, Dale R. and O'Donovan, Claire and O'Reilly, Paul
F. and Ori, Anil P. S. and Oruc, Lilijana and Ösby, Urban
and Oskarsson, Hogni and Painter, Jodie N. and Parra, José
Guzman and Pedersen, Carsten Bøcker and Pedersen, Marianne
Giørtz and Perry, Amy and Peterson, Roseann E. and
Pettersson, Erik and Peyrot, Wouter J. and Pfennig, Andrea
and Pistis, Giorgio and Purcell, Shaun M. and Quiroz, Jorge
A. and Qvist, Per and Regeer, Eline J. and Reif, Andreas and
Reinbold, Céline S. and Rice, John P. and Riley, Brien P.
and Rivas, Fabio and Rivera, Margarita and Roussos, Panos
and Ruderfer, Douglas M. and Ryu, Euijung and Sánchez-Mora,
Cristina and Schatzberg, Alan F. and Scheftner, William A.
and Schoevers, Robert and Schork, Nicholas J. and Schulte,
Eva C. and Shehktman, Tatyana and Shen, Ling and Shi,
Jianxin and Shilling, Paul D. and Shyn, Stanley I. and
Sigurdsson, Engilbert and Slaney, Claire and Smeland, Olav
B. and Smit, Johannes H. and Smith, Daniel J. and Sobell,
Janet L. and Spijker, Anne T. and Steffens, Michael and
Strauss, John S. and Streit, Fabian and Strohmaier, Jana and
Szelinger, Szabolcs and Tansey, Katherine E. and Teismann,
Henning and Teumer, Alexander and Thompson, Robert C. and
Thompson, Wesley and Thomson, Pippa A. and Thorgeirsson,
Thorgeir E. and Traylor, Matthew and Treutlein, Jens and
Uitterlinden, André G. and Umbricht, Daniel and Vedder,
Helmut and Viktorin, Alexander and Visscher, Peter M. and
Wang, Weiqing and Watson, Stanley J. and Webb, Bradley T.
and Weickert, Cynthia Shannon and Weickert, Thomas W. and
Weinsheimer, Shantel Marie and Wellmann, Jürgen and
Willemsen, Gonneke and Witt, Stephanie H. and Wu, Yang and
Xi, Hualin S. and Xu, Wei and Yang, Jian and Young, Allan H.
and Zandi, Peter and Zhang, Peng and Zhang, Futao and
Zollner, Sebastian and Adolfsson, Rolf and Agartz, Ingrid
and Alda, Martin and Arolt, Volker and Backlund, Lena and
Baune, Bernhard T. and Bellivier, Frank and Berger, Klaus
and Berrettini, Wade H. and Biernacka, Joanna M. and
Blackwood, Douglas H. R. and Boehnke, Michael and Boomsma,
Dorret I. and Corvin, Aiden and Craddock, Nicholas and Daly,
Mark J. and Dannlowski, Udo and Domenici, Enrico and
Domschke, Katharina and Esko, Tõnu and Etain, Bruno and
Frye, Mark and Fullerton, Janice M. and Gershon, Elliot S.
and de Geus, E. J. C. and Gill, Michael and Goes, Fernando
and Grabe, Hans J. and Grigoroiu-Serbanescu, Maria and
Hamilton, Steven P. and Hauser, Joanna and Hayward, Caroline
and Heath, Andrew C. and Hougaard, David M. and Hultman,
Christina M. and Jones, Ian and Jones, Lisa A. and Kahn,
René S. and Kendler, Kenneth S. and Kirov, George and
Kloiber, Stefan and Landén, Mikael and Leboyer, Marion and
Lewis, Glyn and Li, Qingqin S. and Lissowska, Jolanta and
Lucae, Susanne and Madden, Pamela A. F. and Magnusson,
Patrik K. and Martin, Nicholas G. and Mayoral, Fermin and
McElroy, Susan L. and McIntosh, Andrew M. and McMahon,
Francis J. and Melle, Ingrid and Metspalu, Andres and
Mitchell, Philip B. and Morken, Gunnar and Mors, Ole and
Mortensen, Preben Bo and Müller-Myhsok, Bertram and Myers,
Richard M. and Neale, Benjamin M. and Nimgaonkar, Vishwajit
and Nordentoft, Merete and Nöthen, Markus M. and O'Donovan,
Michael C. and Oedegaard, Ketil J. and Owen, Michael J. and
Paciga, Sara A. and Pato, Carlos and Pato, Michele T. and
Pedersen, Nancy L. and Penninx, Brenda W. J. H. and Perlis,
Roy H. and Porteous, David J. and Posthuma, Danielle and
Potash, James B. and Preisig, Martin and Ramos-Quiroga,
Josep Antoni and Ribasés, Marta and Rietschel, Marcella and
Rouleau, Guy A. and Schaefer, Catherine and Schalling,
Martin and Schofield, Peter R. and Schulze, Thomas G. and
Serretti, Alessandro and Smoller, Jordan W. and Stefansson,
Hreinn and Stefansson, Kari and Stordal, Eystein and
Tiemeier, Henning and Turecki, Gustavo and Uher, Rudolf and
Vaaler, Arne E. and Vieta, Eduard and Vincent, John B. and
Völzke, Henry and Weissman, Myrna M. and Werge, Thomas and
Andreassen, Ole A. and Børglum, Anders D. and Cichon, Sven
and Edenberg, Howard J. and Di Florio, Arianna and Kelsoe,
John and Levinson, Douglas F. and Lewis, Cathryn M. and
Nurnberger, John I. and Ophoff, Roel A. and Scott, Laura J.
and Sklar, Pamela and Sullivan, Patrick F. and Wray, Naomi
R. and Byrne, Enda M. and Forstner, Andreas J. and Holmans,
Peter A. and de Leeuw, Christiaan A. and Mattheisen, Manuel
and McQuillin, Andrew and Whitehead Pavlides, Jennifer M.
and Pers, Tune H. and Ripke, Stephan and Stahl, Eli A. and
Steinberg, Stacy and Trubetskoy, Vassily and Trzaskowski,
Maciej and Wang, Yunpeng and Abbott, Liam and Abdellaoui,
Abdel and Adams, Mark J. and Adolfsson, Annelie Nordin and
Agerbo, Esben and Akil, Huda and Albani, Diego and
Alliey-Rodriguez, Ney and Als, Thomas D. and Andlauer, Till
F. M. and Anjorin, Adebayo and Antilla, Verneri and Van der
Auwera, Sandra and Awasthi, Swapnil and Bacanu, Silviu-Alin
and Badner, Judith A. and Bækvad-Hansen, Marie and Barchas,
Jack D. and Bass, Nicholas and Bauer, Michael and Beekman,
Aartjan T. F. and Belliveau, Richard and Bergen, Sarah E.
and Bigdeli, Tim B. and Binder, Elisabeth B. and Bøen,
Erlend and Boks, Marco and Boocock, James and Budde, Monika
and Bunney, William and Burmeister, Margit and Buttenschøn,
Henriette N. and Bybjerg-Grauholm, Jonas and Byerley,
William and Cai, Na and Casas, Miquel and Castelao, Enrique
and Cerrato, Felecia and Cervantes, Pablo and Chambert,
Kimberly and Charney, Alexander W. and Chen, Danfeng and
Christensen, Jane Hvarregaard and Churchhouse, Claire and St
Clair, David and Clarke, Toni-Kim and Colodro-Conde, Lucía
and Coryell, William and Couvy-Duchesne, Baptiste and Craig,
David W. and Crawford, Gregory E. and Cruceanu, Cristiana
and Czerski, Piotr M. and Dale, Anders M. and Davies, Gail
and Deary, Ian J. and Degenhardt, Franziska and Del-Favero,
Jurgen and DePaulo, J Raymond and Derks, Eske M. and Direk,
Nese and Djurovic, Srdjan and Dobbyn, Amanda L. and Dolan,
Conor V. and Dumont, Ashley and Dunn, Erin C. and Eley,
Thalia C. and Elvsåshagen, Torbjørn and Escott-Price,
Valentina and Fan, Chun Chieh and Finucane, Hilary K. and
Fischer, Sascha B. and Flickinger, Matthew and Foo, Jerome
C. and Foroud, Tatiana M. and Forty, Liz and Frank, Josef
and Fraser, Christine and Freimer, Nelson B. and Frisén,
Louise and Gade, Katrin and Gage, Diane and Garnham, Julie
and Giambartolomei, Claudia and Goes, Fernando S. and
Goldstein, Jaqueline and Gordon, Scott D. and Gordon-Smith,
Katherine and Green, Elaine K. and Green, Melissa J. and
Greenwood, Tiffany A. and Grove, Jakob and Guan, Weihua and
Hall, Lynsey S. and Hamshere, Marian L. and Hansen,
Christine Søholm and Hansen, Thomas F. and Hautzinger,
Martin and Heilbronner, Urs and van Hemert, Albert M. and
Herms, Stefan and Hickie, Ian B. and Hipolito, Maria and
Hoffmann, Per and Holland, Dominic and Homuth, Georg and
Horn, Carsten and Hottenga, Jouke-Jan and Huckins, Laura and
Ising, Marcus and Jamain, Stéphane and Jansen, Rick and
Johnson, Jessica S. and de Jong, Simone and Jorgenson, Eric
and Juréus, Anders and Kandaswamy, Radhika and Karlsson,
Robert and Kennedy, James L. and Hassan Kiadeh, Farnush
Farhadi and Kittel-Schneider, Sarah and Knowles, James A.
and Kogevinas, Manolis and Kohane, Isaac S. and Koller, Anna
C. and Kraft, Julia and Kretzschmar, Warren W. and Krogh,
Jesper and Kupka, Ralph and Kutalik, Zoltán and Lavebratt,
Catharina and Lawrence, Jacob and Lawson, William B. and
Leber, Markus and Lee, Phil H. and Levy, Shawn E. and Li,
Jun Z. and Li, Yihan and Lind, Penelope A. and Liu, Chunyu
and Olde Loohuis, Loes M. and Maaser, Anna and MacIntyre,
Donald J. and MacKinnon, Dean F. and Mahon, Pamela B. and
Maier, Wolfgang and Maier, Robert M. and Marchini, Jonathan
and Martinsson, Lina and Mbarek, Hamdi and McCarroll, Steve
and McGrath, Patrick and McGuffin, Peter and McInnis, Melvin
G. and McKay, James D. and Medeiros, Helena and Medland,
Sarah E. and Mehta, Divya and Meng, Fan and Middeldorp,
Christel M. and Mihailov, Evelin and Milaneschi, Yuri and
Milani, Lili and Mirza, Saira Saeed and Mondimore, Francis
M. and Montgomery, Grant W. and Morris, Derek W. and
Mostafavi, Sara and Mühleisen, Thomas W. and Mullins, Niamh
and Nauck, Matthias and Ng, Bernard and Nguyen, Hoang and
Nievergelt, Caroline M. and Nivard, Michel G. and Nwulia,
Evaristus A. and Nyholt, Dale R. and O'Donovan, Claire and
O'Reilly, Paul F. and Ori, Anil P. S. and Oruc, Lilijana and
Ösby, Urban and Oskarsson, Hogni and Painter, Jodie N. and
Parra, José Guzman and Pedersen, Carsten Bøcker and
Pedersen, Marianne Giørtz and Perry, Amy and Peterson,
Roseann E. and Pettersson, Erik and Peyrot, Wouter J. and
Pfennig, Andrea and Pistis, Giorgio and Purcell, Shaun M.
and Quiroz, Jorge A. and Qvist, Per and Regeer, Eline J. and
Reif, Andreas and Reinbold, Céline S. and Rice, John P. and
Riley, Brien P. and Rivas, Fabio and Rivera, Margarita and
Roussos, Panos and Ruderfer, Douglas M. and Ryu, Euijung and
Sánchez-Mora, Cristina and Schatzberg, Alan F. and
Scheftner, William A. and Schoevers, Robert and Schork,
Nicholas J. and Schulte, Eva C. and Shehktman, Tatyana and
Shen, Ling and Shi, Jianxin and Shilling, Paul D. and Shyn,
Stanley I. and Sigurdsson, Engilbert and Slaney, Claire and
Smeland, Olav B. and Smit, Johannes H. and Smith, Daniel J.
and Sobell, Janet L. and Spijker, Anne T. and Steffens,
Michael and Strauss, John S. and Streit, Fabian and
Strohmaier, Jana and Szelinger, Szabolcs and Tansey,
Katherine E. and Teismann, Henning and Teumer, Alexander and
Thompson, Robert C. and Thompson, Wesley and Thomson, Pippa
A. and Thorgeirsson, Thorgeir E. and Traylor, Matthew and
Treutlein, Jens and Uitterlinden, André G. and Umbricht,
Daniel and Vedder, Helmut and Viktorin, Alexander and
Visscher, Peter M. and Wang, Weiqing and Watson, Stanley J.
and Webb, Bradley T. and Weickert, Cynthia Shannon and
Weickert, Thomas W. and Weinsheimer, Shantel Marie and
Wellmann, Jürgen and Willemsen, Gonneke and Witt, Stephanie
H. and Wu, Yang and Xi, Hualin S. and Xu, Wei and Yang, Jian
and Young, Allan H. and Zandi, Peter and Zhang, Peng and
Zhang, Futao and Zollner, Sebastian and Adolfsson, Rolf and
Agartz, Ingrid and Alda, Martin and Arolt, Volker and
Backlund, Lena and Baune, Bernhard T. and Bellivier, Frank
and Berger, Klaus and Berrettini, Wade H. and Biernacka,
Joanna M. and Blackwood, Douglas H. R. and Boehnke, Michael
and Boomsma, Dorret I. and Corvin, Aiden and Craddock,
Nicholas and Daly, Mark J. and Dannlowski, Udo and Domenici,
Enrico and Domschke, Katharina and Esko, Tõnu and Etain,
Bruno and Frye, Mark and Fullerton, Janice M. and Gershon,
Elliot S. and de Geus, E. J. C. and Gill, Michael and Goes,
Fernando and Grabe, Hans J. and Grigoroiu-Serbanescu, Maria
and Hamilton, Steven P. and Hauser, Joanna and Hayward,
Caroline and Heath, Andrew C. and Hougaard, David M. and
Hultman, Christina M. and Jones, Ian and Jones, Lisa A. and
Kahn, René S. and Kendler, Kenneth S. and Kirov, George and
Kloiber, Stefan and Landén, Mikael and Leboyer, Marion and
Lewis, Glyn and Li, Qingqin S. and Lissowska, Jolanta and
Lucae, Susanne and Madden, Pamela A. F. and Magnusson,
Patrik K. and Martin, Nicholas G. and Mayoral, Fermin and
McElroy, Susan L. and McIntosh, Andrew M. and McMahon,
Francis J. and Melle, Ingrid and Metspalu, Andres and
Mitchell, Philip B. and Morken, Gunnar and Mors, Ole and
Mortensen, Preben Bo and Müller-Myhsok, Bertram and Myers,
Richard M. and Neale, Benjamin M. and Nimgaonkar, Vishwajit
and Nordentoft, Merete and Nöthen, Markus M. and O'Donovan,
Michael C. and Oedegaard, Ketil J. and Owen, Michael J. and
Paciga, Sara A. and Pato, Carlos and Pato, Michele T. and
Pedersen, Nancy L. and Penninx, Brenda W. J. H. and Perlis,
Roy H. and Porteous, David J. and Posthuma, Danielle and
Potash, James B. and Preisig, Martin and Ramos-Quiroga,
Josep Antoni and Ribasés, Marta and Rietschel, Marcella and
Rouleau, Guy A. and Schaefer, Catherine and Schalling,
Martin and Schofield, Peter R. and Schulze, Thomas G. and
Serretti, Alessandro and Smoller, Jordan W. and Stefansson,
Hreinn and Stefansson, Kari and Stordal, Eystein and
Tiemeier, Henning and Turecki, Gustavo and Uher, Rudolf and
Vaaler, Arne E. and Vieta, Eduard and Vincent, John B. and
Völzke, Henry and Weissman, Myrna M. and Werge, Thomas and
Andreassen, Ole A. and Børglum, Anders D. and Cichon, Sven
and Edenberg, Howard J. and Di Florio, Arianna and Kelsoe,
John and Levinson, Douglas F. and Lewis, Cathryn M. and
Nurnberger, John I. and Ophoff, Roel A. and Scott, Laura J.
and Sklar, Pamela},
title = {{T}he {G}enetics of the {M}ood {D}isorder {S}pectrum:
{G}enome-wide {A}ssociation {A}nalyses of {M}ore {T}han
185,000 {C}ases and 439,000 {C}ontrols.},
journal = {Biological psychiatry},
volume = {88},
number = {2},
issn = {0006-3223},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2020-00836},
pages = {P169-184,},
year = {2020},
abstract = {Mood disorders (including major depressive disorder and
bipolar disorder) affect $10\%$ to $20\%$ of the population.
They range from brief, mild episodes to severe,
incapacitating conditions that markedly impact lives.
Multiple approaches have shown considerable sharing of risk
factors across mood disorders despite their diagnostic
distinction.To clarify the shared molecular genetic basis of
major depressive disorder and bipolar disorder and to
highlight disorder-specific associations, we meta-analyzed
data from the latest Psychiatric Genomics Consortium
genome-wide association studies of major depression
(including data from 23andMe) and bipolar disorder, and an
additional major depressive disorder cohort from UK Biobank
(total: 185,285 cases, 439,741 controls; nonoverlapping N =
609,424).Seventy-three loci reached genome-wide significance
in the meta-analysis, including 15 that are novel for mood
disorders. More loci from the Psychiatric Genomics
Consortium analysis of major depression than from that for
bipolar disorder reached genome-wide significance. Genetic
correlations revealed that type 2 bipolar disorder
correlates strongly with recurrent and single-episode major
depressive disorder. Systems biology analyses highlight both
similarities and differences between the mood disorders,
particularly in the mouse brain cell types implicated by the
expression patterns of associated genes. The mood disorders
also differ in their genetic correlation with educational
attainment-the relationship is positive in bipolar disorder
but negative in major depressive disorder.The mood disorders
share several genetic associations, and genetic studies of
major depressive disorder and bipolar disorder can be
combined effectively to enable the discovery of variants not
identified by studying either disorder alone. However, we
demonstrate several differences between these disorders.
Analyzing subtypes of major depressive disorder and bipolar
disorder provides evidence for a genetic mood disorders
spectrum.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31926635},
UT = {WOS:000546220800014},
doi = {10.1016/j.biopsych.2019.10.015},
url = {https://juser.fz-juelich.de/record/873593},
}
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