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000873607 1001_ $$0P:(DE-Juel1)158077$$aSchneider, Christian$$b0
000873607 245__ $$aQuantitative serological antibody testing for suspected neuroborreliosis
000873607 260__ $$aBerlin$$bSpringer85301$$c2020
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000873607 520__ $$aObjectiveTo assess the importance of serum IgG/IgM antibody titers for the differentiation of Lyme neuroborreliosis (LNB) from its mimics.MethodThis was a retrospective, cross-sectional study conducted at two German neurological centers. Serological parameters (ELISA or CLIA analysis) and clinical presentation of 28 patients with definite LNB were compared to those of 36 patients with neurological symptoms mimicking LNB (mimics). Analysis was performed using receiver operating characteristic (ROC) and binary logistic regression.ResultsElevated IgG-titers had a high sensitivity for neuroborreliosis in both centers (0.95 and 1.0). The optimal cutoff-values were set to 26.35 in center A (ELISA), and 64.0 in center B (CLIA). Diagnostic specificity was 0.41 and 0.89 in this constellation. Elevated IgM-titers showed a high diagnostic specificity for a cutoff at 68.10 (A) and 47.95 (B) (0.93 and 0.89). Sensitivity was 0.45 and 0.5. Overall diagnostic accuracy was low in both centers (A: IgG AUC = 0.665, IgM AUC = 0.629; B: IgG AUC = 0.917, IgM AUC = 0.556). In logistic regression of antibody titers and clinical measures, prediction of LNB was significantly better than the “null hypothesis”. Clinical measures showed the highest odds ratio.ConclusionData show that in addition to the clinical presentation of patients with symptoms suggesting central or peripheral nervous system manifestation, serum IgG- and IgM-titers help to identify LNB-patients. The results should guide physicians counseling patients with suspected LNB about further diagnostic steps and treatment.
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000873607 7001_ $$0P:(DE-HGF)0$$aSchroeter, Michael$$b4
000873607 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b5$$ufzj
000873607 7001_ $$0P:(DE-HGF)0$$aWunderlich, Gilbert$$b6
000873607 7001_ $$00000-0003-0674-9891$$aLehmann, Helmar C.$$b7$$eCorresponding author
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000873607 999C5 $$1A Mygland$$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1468-1331.2009.02862.x$$pe1 -$$tEur J Neurol$$uMygland A, Ljøstad U, Fingerle V et al (2010) EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol 17(8–16):e1–4. https://doi.org/10.1111/j.1468-1331.2009.02862.x$$v17$$y2010
000873607 999C5 $$1S Nath$$2Crossref$$9-- missing cx lookup --$$a10.1016/S0140-6736(17)32451-0$$p1197 -$$tLancet Lond Engl$$uNath S, Koziarz A, Badhiwala JH et al (2018) Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis. Lancet Lond Engl 391:1197–1204. https://doi.org/10.1016/S0140-6736(17)32451-0$$v391$$y2018
000873607 999C5 $$1DJ Gaucher$$2Crossref$$9-- missing cx lookup --$$a10.1001/archinte.162.16.1904$$p1904 -$$tArch Intern Med$$uGaucher DJ, Perez JA (2002) Subdural hematoma following lumbar puncture. Arch Intern Med 162:1904–1905$$v162$$y2002
000873607 999C5 $$1H Krüger$$2Crossref$$9-- missing cx lookup --$$a10.1007/BF00314373$$p322 -$$tJ Neurol$$uKrüger H, Reuss K, Pulz M et al (1989) Meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: a follow-up study of 72 patients over 27 years. J Neurol 236:322–328$$v236$$y1989
000873607 999C5 $$1J Treib$$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.51.5.1489$$p1489 -$$tNeurology$$uTreib J, Fernandez A, Haass A et al (1998) Clinical and serologic follow-up in patients with neuroborreliosis. Neurology 51:1489–1491$$v51$$y1998
000873607 999C5 $$1P Schwenkenbecher$$2Crossref$$9-- missing cx lookup --$$a10.1186/s12879-016-2112-z$$p90 -$$tBMC Infect Dis$$uSchwenkenbecher P, Pul R, Wurster U et al (2017) Common and uncommon neurological manifestations of neuroborreliosis leading to hospitalization. BMC Infect Dis 17:90. https://doi.org/10.1186/s12879-016-2112-z$$v17$$y2017
000873607 999C5 $$1A Perrier$$2Crossref$$9-- missing cx lookup --$$a10.1164/ajrccm.156.2.9702032$$p492 -$$tAm J Respir Crit Care Med$$uPerrier A, Desmarais S, Goehring C et al (1997) D-dimer testing for suspected pulmonary embolism in outpatients. Am J Respir Crit Care Med 156:492–496. https://doi.org/10.1164/ajrccm.156.2.9702032$$v156$$y1997
000873607 999C5 $$1PS Wells$$2Crossref$$9-- missing cx lookup --$$a10.1056/NEJMoa023153$$p1227 -$$tN Engl J Med$$uWells PS, Anderson DR, Rodger M et al (2003) Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med 349:1227–1235. https://doi.org/10.1056/NEJMoa023153$$v349$$y2003
000873607 999C5 $$1M Zwerink$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ttbdis.2017.12.014$$p594 -$$tTicks Tick-Borne Dis$$uZwerink M, Zomer TP, van Kooten B et al (2018) Predictive value of Borrelia burgdorferi IgG antibody levels in patients referred to a tertiary Lyme centre. Ticks Tick-Borne Dis 9:594–597. https://doi.org/10.1016/j.ttbdis.2017.12.014$$v9$$y2018
000873607 999C5 $$1M Madiyal$$2Crossref$$9-- missing cx lookup --$$a10.7860/JCDR/2016/24108.8921$$pDC22 -$$tJ Clin Diagn Res JCDR$$uMadiyal M, Sagar S, Vishwanath S et al (2016) Comparing assay performance of ELISA and chemiluminescence immunoassay in detecting antibodies to Hepatitis B surface antigen. J Clin Diagn Res JCDR 10:DC22–DC25. https://doi.org/10.7860/JCDR/2016/24108.8921$$v10$$y2016
000873607 999C5 $$1TB Ledue$$2Crossref$$9-- missing cx lookup --$$a10.1128/CVI.00195-08$$p1796 -$$tClin Vaccine Immunol CVI$$uLedue TB, Collins MF, Young J et al (2008) Evaluation of the recombinant VlsE-based liaison chemiluminescence immunoassay for detection of Borrelia burgdorferi and diagnosis of Lyme disease. Clin Vaccine Immunol CVI 15:1796–1804. https://doi.org/10.1128/CVI.00195-08$$v15$$y2008
000873607 999C5 $$1K Riesbeck$$2Crossref$$9-- missing cx lookup --$$a10.1007/s10096-007-0329-x$$p517 -$$tEur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol$$uRiesbeck K, Hammas B (2007) Comparison of an automated Borrelia indirect chemiluminescent immunoassay (CLIA) with a VlsE/C6 ELISA and Immunoblot. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol 26:517–519. https://doi.org/10.1007/s10096-007-0329-x$$v26$$y2007
000873607 999C5 $$1CW Ang$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.diagmicrobio.2015.07.007$$p222 -$$tDiagn Microbiol Infect Dis$$uAng CW, Brandenburg AH, van Burgel ND et al (2015) A Dutch nationwide evaluation of serological assays for detection of Borrelia antibodies in clinically well-defined patients. Diagn Microbiol Infect Dis 83:222–228. https://doi.org/10.1016/j.diagmicrobio.2015.07.007$$v83$$y2015
000873607 999C5 $$1AJ Henningsson$$2Crossref$$9-- missing cx lookup --$$a10.1007/s10096-013-2014-6$$p797 -$$tEur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol$$uHenningsson AJ, Christiansson M, Tjernberg I et al (2014) Laboratory diagnosis of Lyme neuroborreliosis: a comparison of three CSF anti-Borrelia antibody assays. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol 33:797–803. https://doi.org/10.1007/s10096-013-2014-6$$v33$$y2014