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@ARTICLE{Kutovyi:873640,
      author       = {Kutovyi, Yurii and Hlukhova, Hanna and Boichuk, Nazarii and
                      Menger, Marcus and Offenhäusser, Andreas and Vitusevich,
                      Svetlana},
      title        = {{A}myloid-beta peptide detection via aptamer-functionalized
                      nanowire sensors exploiting single-trap phenomena},
      journal      = {Biosensors and bioelectronics},
      volume       = {154},
      issn         = {0956-5663},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2020-00883},
      pages        = {112053 -1-8},
      year         = {2020},
      abstract     = {New highly sensitive direct methods for the early detection
                      of peptides involved in Alzheimer's disease (AD) are
                      required in order to prolong effective and healthy memory
                      and thinking capabilities and also to stop the factors
                      resulting in AD. In this contribution, we report the
                      successful demonstration of a label-free approach for the
                      detection of amyloid-beta (Aβ) peptides by highly selective
                      aptamers immobilized onto the SiO2 surface of the fabricated
                      sensors. A modified single-stranded deoxyribonucleic acid
                      (ssDNA) aptamer was specially designed and synthesized to
                      detect the target amyloid beta-40 sequence (Aβ-40).
                      Electrolyte–insulator–semiconductor (EIS) structures as
                      well as silicon (Si) nanowire (NW) field-effect transistors
                      (FETs) covered with a thin SiO2 dielectric layer have been
                      successfully functionalized with Aβ-40-specific aptamers
                      and used to detect ultra-low concentrations of the target
                      peptide. The binding of amyloid-beta peptides of different
                      concentrations to the surface of the sensors varied in the
                      range from 0.1 pg/ml to 10 μg/ml resulting in a change of
                      the surface potential was registered by the fabricated
                      devices. Moreover, we show that the single-trap phenomena
                      observed in the novel Si two-layer (TL) NW FET structures
                      with advanced characteristic parameters can be effectively
                      used to increase the sensitivity of nanoscale sensors. The
                      obtained experimental data demonstrate a highly sensitive
                      and reliable detection of ultra-low concentrations of the
                      Aβ-40 peptides. This opens up prospects for the development
                      of real-time electrical biosensors for studying and
                      understanding different stages of AD by utilizing Si TL NW
                      FET structures fabricated on the basis of cost-efficient
                      CMOS-compatible technology.},
      cin          = {IBI-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32056959},
      UT           = {WOS:000519667000006},
      doi          = {10.1016/j.bios.2020.112053},
      url          = {https://juser.fz-juelich.de/record/873640},
}