TY  - JOUR
AU  - Bauer, Elena K.
AU  - Stoffels, Gabriele
AU  - Blau, Tobias
AU  - Reifenberger, Guido
AU  - Felsberg, Jörg
AU  - Werner, Jan M.
AU  - Lohmann, Philipp
AU  - Rosen, Jurij
AU  - Ceccon, Garry
AU  - Tscherpel, Caroline
AU  - Rapp, Marion
AU  - Sabel, Michael
AU  - Filss, Christian P.
AU  - Shah, Nadim J.
AU  - Neumaier, Bernd
AU  - Fink, Gereon R.
AU  - Langen, Karl-Josef
AU  - Galldiks, Norbert
TI  - Prediction of survival in patients with IDH-wildtype astrocytic gliomas using dynamic O-(2-[18F]-fluoroethyl)-l-tyrosine PET
JO  - European journal of nuclear medicine and molecular imaging
VL  - 47
SN  - 1619-7089
CY  - Heidelberg [u.a.]
PB  - Springer-Verl.
M1  - FZJ-2020-01016
SP  - 1486–1495
PY  - 2020
AB  - PurposeIntegrated histomolecular diagnostics of gliomas according to the World Health Organization (WHO) classification of 2016 has refined diagnostic accuracy and prediction of prognosis. This study aimed at exploring the prognostic value of dynamic O-(2-[18F]-fluoroethyl)-l-tyrosine (FET) PET in newly diagnosed, histomolecularly classified astrocytic gliomas of WHO grades III or IV.MethodsBefore initiation of treatment, dynamic FET PET imaging was performed in patients with newly diagnosed glioblastoma (GBM) and anaplastic astrocytoma (AA). Static FET PET parameters such as maximum and mean tumour/brain ratios (TBRmax/mean), the metabolic tumour volume (MTV) as well as the dynamic FET PET parameters time-to-peak (TTP) and slope, were obtained. The predictive ability of FET PET parameters was evaluated concerning the progression-free and overall survival (PFS, OS). Using ROC analyses, threshold values for FET PET parameters were obtained. Subsequently, univariate Kaplan-Meier and multivariate Cox regression survival analyses were performed to assess the predictive power of these parameters for survival.ResultsSixty patients (45 GBM and 15 AA patients) of two university centres were retrospectively identified. Patients with isocitrate dehydrogenase (IDH)-mutant or O6-methylguanine-DNA-methyltransferase (MGMT) promoter-methylated tumours had a significantly longer PFS and OS (both P < 0.001). Furthermore, ROC analysis of IDH-wildtype glioma patients (n = 45) revealed that a TTP > 25 min (AUC, 0.90; sensitivity, 90%; specificity, 87%; P < 0.001) was highly prognostic for longer PFS (13 vs. 7 months; P = 0.005) and OS (29 vs. 12 months; P < 0.001). In contrast, at a lower level of significance, TBRmax, TBRmean, and MTV were only prognostic for longer OS (P = 0.004, P = 0.038, and P = 0.048, respectively). Besides complete resection and a methylated MGMT promoter, TTP remained significant in multivariate survival analysis (all P ≤ 0.02), indicating an independent predictor for OS.ConclusionsOur data suggest that dynamic FET PET allows the identification of patients with longer OS among patients with newly diagnosed IDH-wildtype GBM and AA.
LB  - PUB:(DE-HGF)16
C6  - pmid:32034446
UR  - <Go to ISI:>//WOS:000515952800001
DO  - DOI:10.1007/s00259-020-04695-0
UR  - https://juser.fz-juelich.de/record/873811
ER  -