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@ARTICLE{Perfetti:873842,
      author       = {Perfetti, Marco and Gallucci, Noemi and Russo Krauss, Irene
                      and Radulescu, Aurel and Pasini, Stefano and Holderer, Olaf
                      and D’Errico, Gerardino and Vitiello, Giuseppe and
                      Bianchetti, Giulia Ottavia and Paduano, Luigi},
      title        = {{R}evealing the {A}ggregation {M}echanism, {S}tructure, and
                      {I}nternal {D}ynamics of {P}oly(vinyl alcohol) {M}icrogel
                      {P}repared through {L}iquid–{L}iquid {P}hase {S}eparation},
      journal      = {Macromolecules},
      volume       = {53},
      number       = {3},
      issn         = {1520-5835},
      address      = {Washington, DC},
      publisher    = {Am. Chem. Soc.},
      reportid     = {FZJ-2020-01044},
      pages        = {852 - 861},
      year         = {2020},
      abstract     = {The use of technologies based on soft polymer particles
                      represents an effective way to deliver target molecules with
                      a specific function. To design a well-performing delivery
                      system, it is fundamental to rationalize both the
                      aggregation and the structural properties of such particles.
                      In this study, we present the kinetic and structural
                      characterization over time of poly(vinyl alcohol) (PVA)
                      microgels obtained through a salting-out process in the
                      presence of NaCl. We have analyzed how both the polymer and
                      salt concentrations affect the aggregation process. The
                      aggregation rate as well as the morphology and
                      physico-chemical parameters, such as mass and chain density
                      of the microgels, have been determined through static and
                      dynamic light scattering and discussed in the framework of
                      the diffusion-limited and reaction-limited colloid
                      aggregation. Insights into the polymer chain arrangements
                      and their dynamics have been gained by means of small-angle
                      neutron scattering and neutron spin-echo measurements. As a
                      result, it was found that NaCl induces a liquid phase
                      separation in solution with the formation of spherical PVA
                      microaggregates, which grow under a reaction-limited
                      aggregation mechanism. The particles increase their size and
                      compactness over time. Within the aggregate, the polymer
                      chains are locally organized to form randomly oriented
                      lamellae with a thickness of about 60 Å. The internal
                      dynamics is a complex mixture of diffusion, Zimm dynamics,
                      and possibly effects from crowding with the transition to a
                      Rouse-like behavior. The microparticle preparation based on
                      the salting-out process constitutes a novelty, if compared
                      to the methods already existing and based on the use of
                      chemical cross-linkers, and is a cheap and easy protocol
                      that allows tuning both particle size and density by varying
                      the salt concentration.},
      cin          = {JCNS-FRM-II / MLZ / JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6215 / G:(DE-HGF)POF3-6G15 /
                      G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101 / EXP:(DE-MLZ)J-NSE-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000513299100010},
      doi          = {10.1021/acs.macromol.9b02203},
      url          = {https://juser.fz-juelich.de/record/873842},
}