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@ARTICLE{Dong:873862,
      author       = {Dong, Debo and Luo, Cheng and Guell, Xavier and Wang, Yulin
                      and He, Hui and Duan, Mingjun and Eickhoff, Simon and Yao,
                      Dezhong},
      title        = {{C}ompression of cerebellar functional gradients in
                      schizophrenia},
      journal      = {Schizophrenia bulletin},
      volume       = {46},
      number       = {5},
      issn         = {1745-1701},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2020-01054},
      pages        = {1282–1295},
      year         = {2020},
      note         = {This work was partly supported by the grant from the
                      National Key $R\&D$ Program of China (No. 2018YFA0701400),
                      grants from the National Nature Science Foundation of China
                      (No. 61933003, 81771822, 81861128001, and 81771925), the
                      CAMS Innovation Fund for Medical Sciences (CIFMS) (No.
                      2019-I2M-5-039) and the Project of Science and Technology
                      Department of Sichuan Province (No. 2019YJ0179).
                      AcknowledgmentsThe authors declare no conflicts of
                      interests. We are grateful to all the participants in this
                      study. Our thanks also go to Dr. Xi Chen (Civil Aviation
                      Flight University of China) and Mr. Xin Chang (University of
                      Electronic Science and Technology of China) for their help
                      to collect the dataset.},
      abstract     = {Our understanding of cerebellar involvement in brain
                      disorders has evolved from motor processing to high-level
                      cognitive and affective processing. Recent neuroscience
                      progress has highlighted hierarchy as a fundamental
                      principle for the brain organization. Despite substantial
                      research on cerebellar dysfunction in schizophrenia, there
                      is a need to establish a neurobiological framework to better
                      understand the co-occurrence and interaction of low- and
                      high-level functional abnormalities of cerebellum in
                      schizophrenia. To help to establish such a framework, we
                      investigated the abnormalities in the distribution of
                      sensorimotor-supramodal hierarchical processing topography
                      in the cerebellum and cerebellar-cerebral circuits in
                      schizophrenia using a novel gradient-based resting-state
                      Functional-connectivity(FC) analysis (96 patients with
                      schizophrenia vs. 120 healthy controls). We found
                      schizophrenia patients showed a compression of the principal
                      motor-to-supramodal gradient. Specifically, there were
                      increased gradient values in sensorimotor regions and
                      decreased gradient values in supramodal regions, resulting
                      in a shorter distance (compression) between the sensorimotor
                      and supramodal poles of this gradient. This pattern was
                      observed in intra-cerebellar, cerebellar-cerebral, and
                      cerebral-cerebellar FC. Further investigation revealed
                      hyper-connectivity between sensorimotor and cognition areas
                      within cerebellum, between cerebellar sensorimotor and
                      cerebral cognition areas, and between cerebellar cognition
                      and cerebral sensorimotor areas, possibly contributing to
                      the observed compressed pattern. These findings present a
                      novel mechanism that may underlie the co-occurrence and
                      interaction of low- and high-level functional abnormalities
                      of cerebellar and cerebro-cerebellar circuits in
                      schizophrenia. Within this framework of abnormal
                      motor-to-supramodal organization, a cascade of impairments
                      stemming from disrupted low-level sensorimotor system may in
                      part account for high-level cognitive cerebellar dysfunction
                      in schizophrenia.Keywords: Schizophrenia; Sensorimotor;
                      Cerebellum; Cerebellar-cerebral Circuits; Resting-state
                      Functional connectivity; Functional Gradient},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32144421},
      UT           = {WOS:000593174100030},
      doi          = {10.1093/schbul/sbaa016},
      url          = {https://juser.fz-juelich.de/record/873862},
}