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000873888 1001_ $$0P:(DE-Juel1)131702$$aQi, Guanxiao$$b0$$eCorresponding author$$ufzj
000873888 245__ $$aUnveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons
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000873888 520__ $$aSynaptic transmission between neurons is the basic mechanism for information processing in cortical microcircuits. To date, paired recording from synaptically coupled neurons is the most widely used method which allows a detailed functional characterization of unitary synaptic transmission at the cellular and synaptic level in combination with a structural characterization of both pre- and postsynaptic neurons at the light and electron microscopic level. In this review, we will summarize the many applications of paired recordings to investigate synaptic function and structure. Paired recordings have been used to study the detailed electrophysiological and anatomical properties of synaptically coupled cell pairs within a synaptic microcircuit; this is critical in order to understand the connectivity rules and dynamic properties of synaptic transmission. Paired recordings can also be adopted for quantal analysis of an identified synaptic connection and to study the regulation of synaptic transmission by neuromodulators such as acetylcholine, the monoamines, neuropeptides, and adenosine etc. Taken together, paired recordings from synaptically coupled neurons will remain a very useful approach for a detailed characterization of synaptic transmission not only in the rodent brain but also that of other species including humans.
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000873888 7001_ $$0P:(DE-Juel1)169634$$aYang, Danqing$$b1$$ufzj
000873888 7001_ $$0P:(DE-Juel1)164184$$aDing, Chao$$b2$$ufzj
000873888 7001_ $$0P:(DE-Juel1)131680$$aFeldmeyer, Dirk$$b3$$ufzj
000873888 773__ $$0PERI:(DE-600)2592086-8$$a10.3389/fnsyn.2020.00005$$gVol. 12, p. 5$$p5$$tFrontiers in synaptic neuroscience$$v12$$x1663-3563$$y2020
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