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@INBOOK{Ripp:873903,
      author       = {Bernis, Maria Eugenia and Tamgüney, Gültekin},
      editor       = {Ripp, Steven},
      title        = {{B}ioluminescence {I}maging of {N}euroinflammation in a
                      {M}ouse {M}odel of {P}arkinson’s {D}isease},
      volume       = {2081},
      address      = {New York, NY},
      publisher    = {Springer US},
      reportid     = {FZJ-2020-01088},
      isbn         = {978-1-4939-9940-8},
      series       = {Methods in Molecular Biology},
      pages        = {147 - 159},
      year         = {2020},
      comment      = {Bioluminescent Imaging / Ripp, Steven (Editor) ; New York,
                      NY : Springer US, 2020, Chapter 10 ; ISSN:
                      1064-3745=1940-6029 ; ISBN:
                      978-1-4939-9939-2=978-1-4939-9940-8 ;
                      doi:10.1007/978-1-4939-9940-8},
      booktitle     = {Bioluminescent Imaging / Ripp, Steven
                       (Editor) ; New York, NY : Springer US,
                       2020, Chapter 10 ; ISSN:
                       1064-3745=1940-6029 ; ISBN:
                       978-1-4939-9939-2=978-1-4939-9940-8 ;
                       doi:10.1007/978-1-4939-9940-8},
      abstract     = {In Parkinson’s disease (PD) and related disorders
                      pathological alpha-synuclein has been discussed to propagate
                      via a prion-like mechanism in the CNS. The application of
                      exogenous alpha-synuclein fibrils via injection to animal
                      models of PD has been shown to be a useful method to study
                      prion-like propagation of pathological alpha-synuclein and
                      of transmission pathways that play a critical role in
                      recapitulating characteristics of synucleinopathies. Using
                      bigenic mice expressing mutant human alpha-synuclein in
                      neurons and firefly luciferase in astrocytes we showed that
                      transmission via the tongue and the peritoneum represent
                      entrance points for pathological alpha-synuclein to invade
                      the CNS. Here we present a method to quantify astrogliosis
                      by bioluminescence imaging in an animal model of PD. This
                      method allows noninvasive tracking of the neuroinflammatory
                      process that often precedes neurological signs of disease
                      and represents an alternative to behavioral or histological
                      and biochemical analysis to detect disease.},
      cin          = {ICS-6},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)7},
      pubmed       = {pmid:31721123},
      UT           = {WOS:000565914400011},
      doi          = {10.1007/978-1-4939-9940-8_10},
      url          = {https://juser.fz-juelich.de/record/873903},
}