Hauptseite > Publikationsdatenbank > Bioluminescence Imaging of Neuroinflammation in a Mouse Model of Parkinson’s Disease > print

001     873903
005     20210130004534.0
020 _ _ |a 978-1-4939-9940-8
020 _ _ |a 978-1-4939-9940-8 (electronic)
024 7 _ |a 10.1007/978-1-4939-9940-8_10
|2 doi
024 7 _ |a 1064-3745
|2 ISSN
024 7 _ |a 1940-6029
|2 ISSN
024 7 _ |a altmetric:70342252
|2 altmetric
024 7 _ |a pmid:31721123
|2 pmid
024 7 _ |a WOS:000565914400011
|2 WOS
037 _ _ |a FZJ-2020-01088
082 _ _ |a 570
100 1 _ |a Ripp, Steven
|0 P:(DE-HGF)0
|b 0
|e Editor
245 _ _ |a Bioluminescence Imaging of Neuroinflammation in a Mouse Model of Parkinson’s Disease
260 _ _ |a New York, NY
|c 2020
|b Springer US
295 1 0 |a Bioluminescent Imaging / Ripp, Steven (Editor) ; New York, NY : Springer US, 2020, Chapter 10 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-9939-2=978-1-4939-9940-8 ; doi:10.1007/978-1-4939-9940-8
300 _ _ |a 147 - 159
336 7 _ |a BOOK_CHAPTER
|2 ORCID
336 7 _ |a Book Section
|0 7
|2 EndNote
336 7 _ |a bookPart
|2 DRIVER
336 7 _ |a INBOOK
|2 BibTeX
336 7 _ |a Output Types/Book chapter
|2 DataCite
336 7 _ |a Contribution to a book
|b contb
|m contb
|0 PUB:(DE-HGF)7
|s 1582006202_479
|2 PUB:(DE-HGF)
490 0 _ |a Methods in Molecular Biology
|v 2081
520 _ _ |a In Parkinson’s disease (PD) and related disorders pathological alpha-synuclein has been discussed to propagate via a prion-like mechanism in the CNS. The application of exogenous alpha-synuclein fibrils via injection to animal models of PD has been shown to be a useful method to study prion-like propagation of pathological alpha-synuclein and of transmission pathways that play a critical role in recapitulating characteristics of synucleinopathies. Using bigenic mice expressing mutant human alpha-synuclein in neurons and firefly luciferase in astrocytes we showed that transmission via the tongue and the peritoneum represent entrance points for pathological alpha-synuclein to invade the CNS. Here we present a method to quantify astrogliosis by bioluminescence imaging in an animal model of PD. This method allows noninvasive tracking of the neuroinflammatory process that often precedes neurological signs of disease and represents an alternative to behavioral or histological and biochemical analysis to detect disease.
536 _ _ |a 553 - Physical Basis of Diseases (POF3-553)
|0 G:(DE-HGF)POF3-553
|c POF3-553
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef Book Series
700 1 _ |a Bernis, Maria Eugenia
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Tamgüney, Gültekin
|0 P:(DE-Juel1)177986
|b 2
|e Corresponding author
773 _ _ |a 10.1007/978-1-4939-9940-8_10
856 4 _ |u https://juser.fz-juelich.de/record/873903/files/Bioluminescence%20imaging%20of%20neuroinflammation%20in%20a%20mouse%20model%20of%20Parkinson%27s%20disease.pdf
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/873903/files/Bioluminescence%20imaging%20of%20neuroinflammation%20in%20a%20mouse%20model%20of%20Parkinson%27s%20disease.pdf?subformat=pdfa
|x pdfa
|y Restricted
909 C O |o oai:juser.fz-juelich.de:873903
|p VDB
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 2
|6 P:(DE-Juel1)177986
913 1 _ |a DE-HGF
|b Key Technologies
|l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences
|1 G:(DE-HGF)POF3-550
|0 G:(DE-HGF)POF3-553
|2 G:(DE-HGF)POF3-500
|v Physical Basis of Diseases
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2020
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)ICS-6-20110106
|k ICS-6
|l Strukturbiochemie
|x 0
980 _ _ |a contb
980 _ _ |a VDB
980 _ _ |a I:(DE-Juel1)ICS-6-20110106
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)IBI-7-20200312

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21