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@ARTICLE{Votinov:873910,
      author       = {Votinov, Mikhail and Wagels, Lisa and Hoffstaedter, Felix
                      and Kellermann, Thilo and Goerlich, Katharina S. and
                      Eickhoff, Simon B. and Habel, Ute},
      title        = {{E}ffects of exogenous testosterone application on network
                      connectivity within emotion regulation systems},
      journal      = {Scientific reports},
      volume       = {10},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2020-01095},
      pages        = {2352},
      year         = {2020},
      note         = {This work was supported via internal funding by the
                      interdisciplinary center for clinical research (IZKF Aachen;
                      grant number N 7–7) of the School of Medicine, RWTH Aachen
                      University, as a part of a joint project on alterations of
                      neural connectivity. In addition, the project was supported
                      by the German Research Foundation (DFG, IRTG 2150). The
                      funding sources had no role in study design, in the
                      collection, analysis, and interpretation of data, in the
                      writing of the report, and in the decision to submit the
                      article for publication. There are no conflicts of
                      interest.},
      abstract     = {Studies with steroid hormones underlined the vital role of
                      testosterone on social-emotional processing. However, there
                      is still a lack of studies investigating whether
                      testosterone modulates network connectivity during
                      resting-state. Here, we tested how the exogenous application
                      of testosterone would affect functional connectivity between
                      regions implicated in emotion regulation. In total, 96 male
                      participants underwent resting-state fMRI scanning. Before
                      the measurement, half of the subjects received 5 g
                      TestimTM gel (containing 50 mg testosterone) and the other
                      half a corresponding amount of placebo gel. Seeds for the
                      connectivity analysis were meta-analytically defined. First,
                      all regions associated with emotion regulation were chosen
                      via Neurosynth (data driven). Among those, specific seeds
                      were selected and categorized based on the neural model of
                      emotion regulation by Etkin and colleagues (Etkin et al.,
                      2015) (theory-guided). Resting-state connectivity analysis
                      revealed decreased connectivity between the right DLPFC and
                      the right amygdala as well as between the VMPFC and the left
                      IPL for the testosterone group compared to the placebo
                      group. A complementary dynamic causal modeling (DCM)
                      analysis on findings from the resting-state connectivity
                      analysis underlined a bidirectional coupling which was
                      decreased close to zero by testosterone administration. Our
                      results demonstrate that testosterone administration
                      disrupts resting-state connectivity within
                      fronto-subcortical and fronto-parietal circuits. The
                      findings suggest that even without a specific task (e.g.
                      challenge, reward processing) testosterone modulates brain
                      networks important for social-emotional processing.},
      cin          = {INM-7 / INM-10},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-10-20170113},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32047245},
      UT           = {WOS:000562858200003},
      doi          = {10.1038/s41598-020-59329-0},
      url          = {https://juser.fz-juelich.de/record/873910},
}