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@ARTICLE{Bogorodskiy:874243,
      author       = {Bogorodskiy, Andrey O. and Bolkhovitina, Elena L. and
                      Gensch, Thomas and Troyanova, Natalia I. and Mishin, Alexey
                      V. and Okhrimenko, Ivan S. and Braun, Armin and Spies, Emma
                      and Gordeliy, Valentin I. and Sapozhnikov, Alexander M. and
                      Borshchevskiy, Valentin I. and Shevchenko, Marina A.},
      title        = {{M}urine {I}ntraepithelial {D}endritic {C}ells {I}nteract
                      {W}ith {P}hagocytic {C}ells {D}uring {A}spergillus
                      fumigatus-{I}nduced {I}nflammation},
      journal      = {Frontiers in immunology},
      volume       = {11},
      issn         = {1664-3224},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {FZJ-2020-01334},
      pages        = {298},
      year         = {2020},
      abstract     = {People are constantly exposed to airborne fungal spores,
                      including Aspergillus fumigatus conidia that can cause
                      life-threatening conditions in immunocompromised patients or
                      acute exacerbations in allergics. However, immunocompetent
                      hosts do not exhibit mycoses or systemic inflammation, due
                      to the sufficient but not excessive antifungal immune
                      response that prevent fungal invasion. Intraepithelial
                      dendritic cells (IE-DCs) of the conducting airway mucosa are
                      located in the primary site of the inhalant pathogen entry;
                      these cells can sense A. fumigatus conidia and maintain
                      homeostasis. The mechanisms by which IE-DCs contribute to
                      regulating the antifungal immune response and controlling
                      conidia dissemination are not understood. To clarify the
                      role of IE-DCs in the balance between pathogen sensing and
                      immune tolerance we investigated the A. fumigatus conidia
                      distribution in optically cleared mouse lungs and estimated
                      the kinetics of the local phagocytic response during the
                      course of inflammation. MHCII+ antigen-presenting cells,
                      including IE-DCs, and CD11b+ phagocytes were identified by
                      immunohistochemistry and three-dimensional fluorescence
                      confocal laser-scanning microscopy of conducting airway
                      whole-mounts. Application of A. fumigatus conidia increased
                      the number of CD11b+ phagocytes in the conducting airway
                      mucosa and induced the trafficking of these cells through
                      the conducting airway wall to the luminal side of the
                      epithelium. Some CD11b+ phagocytes internalized conidia in
                      the conducting airway lumen. During the migration through
                      the airway wall, CD11b+ phagocytes formed clusters.
                      Permanently located in the airway wall IE-DCs contacted both
                      single CD11b+ phagocytes and clusters. Based on the
                      spatiotemporal characteristics of the interactions between
                      IE-DCs and CD11b+ phagocytes, we provide a novel anatomical
                      rationale for the contribution of IE-DCs to controlling the
                      excessive phagocyte-mediated immune response rather than
                      participating in pathogen uptake.},
      cin          = {ICS-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32161590},
      UT           = {WOS:000524789000001},
      doi          = {10.3389/fimmu.2020.00298},
      url          = {https://juser.fz-juelich.de/record/874243},
}