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@ARTICLE{Gray:874260,
      author       = {Gray, Jodie P. and Müller, Veronika I. and Eickhoff, Simon
                      B. and Fox, Peter T.},
      title        = {{M}ultimodal {A}bnormalities of {B}rain {S}tructure and
                      {F}unction in {M}ajor {D}epressive {D}isorder: {A}
                      {M}eta-{A}nalysis of {N}euroimaging {S}tudies},
      journal      = {The American journal of psychiatry},
      volume       = {177},
      number       = {5},
      issn         = {1535-7228},
      address      = {Stanford, Calif.},
      publisher    = {HighWire Press},
      reportid     = {FZJ-2020-01351},
      pages        = {422-434},
      year         = {2020},
      note         = {Disclosures: Ms. Gray has received research-training
                      support from a grant through the US Department of Defense;
                      she has received honoraria for speaking from the Mind
                      Science Foundation. Dr. Eickhoff has received research
                      support from the Deutsche Forschungsgemeinschaft, The
                      Helmholtz-Association, The National Institutes of Health,
                      and the European Commission Dr. Fox has received research
                      support from The National Institutes of Health, the US
                      Department of Defense, the US Department of Veterans
                      Affairs, the Cancer Prevention $\&$ Research Institute of
                      Texas, and The Mather’s Foundation. Dr. Müller reports no
                      financial relationships with commercial
                      interests.Acknowledgements: This work was supported by
                      grants from the National Institute of Mental Health
                      (R01-MH074457-14) and the Department of Defense
                      (ISG/W81XWH1320065).},
      abstract     = {AbstractObjective: Imaging studies of major depressive
                      disorder (MDD) have reported structural and functional
                      abnormalities in many, spatially diverse brain regions.
                      Quantitative meta-analyses of this literature, however, have
                      failed to find statistically significant between-study
                      spatial convergence, other than transdiagnostic-only
                      effects. In the present study, the authors apply a novel,
                      multi-modal, meta-analytic approach to test the hypothesis
                      that MDD exhibits spatially convergent structural and
                      functional brain abnormalities.Methods: This
                      coordinate-based meta-analysis (CBMA) included voxel-based
                      morphometry (VBM) studies and resting-state voxel-based
                      pathophysiology (VBP) studies imaging blood flow (BF),
                      glucose metabolism, regional homogeneity (ReHo), and
                      amplitude of low frequency fluctuations (ALFF/fALFF). Input
                      data were grouped into three primary meta-analytic classes:
                      gray matter atrophy; increased function; and, decreased
                      function in MDD patients relative to healthy controls.
                      Secondary meta-analyses grouped across primary categories.
                      Tertiary analyses grouped by medication status and absence
                      of psychiatric comorbidity. Activation likelihood estimation
                      (ALE) was used for all analyses.Results: In total 92
                      publications reporting 152 experiments were identified,
                      collectively representing 2,928 MDD patients. Primary
                      analyses detected no convergence across studies. Secondary
                      analyses identified portions of subgenual cingulate,
                      hippocampus, amygdala, putamen, retrosplenial cortex, and
                      middle occipital/inferior temporal gyri as demonstrating
                      convergent abnormalities. Tertiary analyses (clinical
                      subtypes) showed improved convergence relative to secondary
                      analyses.Conclusions: CBMA identified spatially convergent
                      structural (VBM) and functional (VBP) abnormalities in MDD.
                      Present findings suggest replicable neuroimaging features
                      associated with MDD, beyond the transdiagnostic effects
                      reported in prior meta-analysis. Our findings support
                      continued research focus on the subgenual cingulate and
                      other select regions’ role in MDD.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32098488},
      UT           = {WOS:000537832600010},
      doi          = {10.1176/appi.ajp.2019.19050560},
      url          = {https://juser.fz-juelich.de/record/874260},
}