TY  - CONF
AU  - Berghoff, Marco
AU  - Rosenbauer, Jakob
AU  - Schug, Alexander
TI  - Massively Parallel Large-Scale Multi-Model Simulation of Tumour Development Including Treatments
VL  - 50
CY  - Jülich
PB  - Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
M1  - FZJ-2020-01379
SN  - 978-3-95806-443-0
T2  - Publication Series of the John von Neumann Institute for Computing (NIC) NIC Series
SP  - 63 - 71
PY  - 2020
AB  - The  temporal  and  spatial  resolution  in  the  microscopy  of  tissues  has  increased  significantly within the last years, yielding new insights into the dynamics of tissue development and the role of single cells within it.  Still, the theoretical description of the connection of single cell processes to macroscopic tissue reorganisations is lacking. Especially in tumour development, single cells play a crucial role in the advance of tumour properties.   We developed a simulation framework that can model tissue development up to the centimetre scale with micrometre resolution of single cells.  Through parallelisation, it enables the efficient use of high-performance computing systems, therefore enabling detailed simulations on 10.000s of cores. Our generalised tumour model respects adhesion driven cell migration, cell-to-cell signalling, and mutation-driven tumour heterogeneity.  We scan the response of the tumour development depending on division inhibiting substances such as cytostatic agents.   Furthermore,  we are investigating the interaction with radiotherapy to find a suitable therapy plan.  Currently, the emergence of ever-more-powerful experimental techniques such as light sheet microscopy already offers unprecedented subcellular insight into tissue dynamics.  Combined with powerful machine learning techniques, such large data sets (TB’s +) can be effectively evaluated promising realistic parameters for our simulations for topics ranging from cancer development to embryogenesis  or  morphogenesis  with  considerable  impact  both  for  basic  science  and  applied biomedical fields.
T2  - NIC Symposium 2020
CY  - 27 Feb 2020 - 28 Feb 2020, Jülich (Germany)
Y2  - 27 Feb 2020 - 28 Feb 2020
M2  - Jülich, Germany
LB  - PUB:(DE-HGF)8 ; PUB:(DE-HGF)7
UR  - https://juser.fz-juelich.de/record/874346
ER  -