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000874445 1001_ $$0P:(DE-Juel1)171754$$aRégio Brambilla, Cláudia$$b0$$eCorresponding author
000874445 245__ $$amGluR5 receptor availability is associated with lower levels of negative symptoms and better cognition in male patients with chronic schizophrenia
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000874445 520__ $$aConsistent findings postulate disturbed glutamatergic function (more specifically a hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic mechanism in schizophrenia. However, the role of the metabotropic glutamatergic receptors type 5 (mGluR5) in this disease remains unclear. In this study, we investigated their significance (using [11C]ABP688) for psychopathology and cognition in male patients with chronic schizophrenia and healthy controls. In the patient group, lower mGluR5 binding potential (BPND) values in the left temporal cortex and caudate were associated with higher general symptom levels (negative and depressive symptoms), lower levels of global functioning and worse cognitive performance. At the same time, in both groups, mGluR5 BPND were significantly lower in smokers (F [27,1] = 15.500; p = .001), but without significant differences between the groups. Our findings provide support for the concept that the impaired function of mGluR5 underlies the symptoms of schizophrenia. They further supply a new perspective on the complex relationship between tobacco addiction and schizophrenia by identifying glutamatergic neurotransmission—in particularly mGluR5—as a possible connection to a shared vulnerability.
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000874445 7001_ $$00000-0001-7906-6966$$aVeselinović, Tanja$$b1
000874445 7001_ $$0P:(DE-Juel1)164396$$aRajkumar, Ravichandran$$b2
000874445 7001_ $$0P:(DE-Juel1)144215$$aMauler, Jörg$$b3
000874445 7001_ $$0P:(DE-Juel1)172782$$aOrth, Linda$$b4
000874445 7001_ $$00000-0002-0524-347X$$aRuch, Andrej$$b5
000874445 7001_ $$0P:(DE-Juel1)169201$$aRamkiran, Shukti$$b6
000874445 7001_ $$00000-0001-5105-1922$$aHeekeren, Karsten$$b7
000874445 7001_ $$0P:(DE-HGF)0$$aKawohl, Wolfram$$b8
000874445 7001_ $$0P:(DE-HGF)0$$aWyss, Christine$$b9
000874445 7001_ $$0P:(DE-Juel1)131788$$aKops, Elena Rota$$b10
000874445 7001_ $$0P:(DE-Juel1)131791$$aScheins, Jürgen$$b11$$ufzj
000874445 7001_ $$0P:(DE-Juel1)131797$$aTellmann, Lutz$$b12$$ufzj
000874445 7001_ $$0P:(DE-Juel1)131752$$aBoers, Frank$$b13$$ufzj
000874445 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b14
000874445 7001_ $$0P:(DE-Juel1)131818$$aErmert, Johannes$$b15$$ufzj
000874445 7001_ $$0P:(DE-Juel1)131768$$aHerzog, Hans$$b16$$ufzj
000874445 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl‐Josef$$b17
000874445 7001_ $$00000-0002-8151-6169$$aJon Shah, N.$$b18
000874445 7001_ $$0P:(DE-Juel1)164254$$aLerche, Christoph$$b19
000874445 7001_ $$0P:(DE-Juel1)131781$$aNeuner, Irene$$b20$$ufzj
000874445 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.24976$$gp. hbm.24976$$n10$$p2762-2781$$tHuman brain mapping$$v41$$x1097-0193$$y2020
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