TY  - JOUR
AU  - Régio Brambilla, Cláudia
AU  - Veselinović, Tanja
AU  - Rajkumar, Ravichandran
AU  - Mauler, Jörg
AU  - Orth, Linda
AU  - Ruch, Andrej
AU  - Ramkiran, Shukti
AU  - Heekeren, Karsten
AU  - Kawohl, Wolfram
AU  - Wyss, Christine
AU  - Kops, Elena Rota
AU  - Scheins, Jürgen
AU  - Tellmann, Lutz
AU  - Boers, Frank
AU  - Neumaier, Bernd
AU  - Ermert, Johannes
AU  - Herzog, Hans
AU  - Langen, Karl‐Josef
AU  - Jon Shah, N.
AU  - Lerche, Christoph
AU  - Neuner, Irene
TI  - mGluR5 receptor availability is associated with lower levels of negative symptoms and better cognition in male patients with chronic schizophrenia
JO  - Human brain mapping
VL  - 41
IS  - 10
SN  - 1097-0193
CY  - New York, NY
PB  - Wiley-Liss
M1  - FZJ-2020-01446
SP  - 2762-2781
PY  - 2020
AB  - Consistent findings postulate disturbed glutamatergic function (more specifically a hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic mechanism in schizophrenia. However, the role of the metabotropic glutamatergic receptors type 5 (mGluR5) in this disease remains unclear. In this study, we investigated their significance (using [11C]ABP688) for psychopathology and cognition in male patients with chronic schizophrenia and healthy controls. In the patient group, lower mGluR5 binding potential (BPND) values in the left temporal cortex and caudate were associated with higher general symptom levels (negative and depressive symptoms), lower levels of global functioning and worse cognitive performance. At the same time, in both groups, mGluR5 BPND were significantly lower in smokers (F [27,1] = 15.500; p = .001), but without significant differences between the groups. Our findings provide support for the concept that the impaired function of mGluR5 underlies the symptoms of schizophrenia. They further supply a new perspective on the complex relationship between tobacco addiction and schizophrenia by identifying glutamatergic neurotransmission—in particularly mGluR5—as a possible connection to a shared vulnerability.
LB  - PUB:(DE-HGF)16
C6  - pmid:32150317
UR  - <Go to ISI:>//WOS:000540009000014
DO  - DOI:10.1002/hbm.24976
UR  - https://juser.fz-juelich.de/record/874445
ER  -