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000874448 1001_ $$0P:(DE-Juel1)156479$$aStegmayr, Carina$$b0
000874448 245__ $$aCurrent trends in the use of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) in neurooncology
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000874448 520__ $$aThe diagnostic potential of PET using the amino acid analogue O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) in brain tumor diagnostics has been proven in many studies during the last two decades and is still the subject of multiple studies every year. In addition to standard magnetic resonance imaging (MRI), positron emission tomography (PET) using [18F]FET provides important diagnostic data concerning brain tumor delineation, therapy planning, treatment monitoring, and improved differentiation between treatment-related changes and tumor recurrence. The pharmacokinetics, uptake mechanisms and metabolism have been well described in various preclinical studies. The accumulation of [18F]FET in most benign lesions and healthy brain tissue has been shown to be low, thus providing a high contrast between tumor tissue and benign tissue alterations. Based on logistic advantages of F-18 labelling and convincing clinical results, [18F]FET has widely replaced short lived amino acid tracers such as L-[11C]methyl-methionine ([11C]MET) in many centers across Western Europe. This review summarizes the basic knowledge on [18F]FET and its contribution to the care of patients with brain tumors. In particular, recent studies about specificity, possible pitfalls, and the utility of [18F]FET PET in tumor grading and prognostication regarding the revised WHO classification of brain tumors are addressed.
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000874448 7001_ $$0P:(DE-Juel1)131627$$aStoffels, Gabriele$$b1
000874448 7001_ $$0P:(DE-HGF)0$$aFilß, Christian$$b2
000874448 7001_ $$0P:(DE-Juel1)132315$$aHeinzel, Alexander$$b3
000874448 7001_ $$0P:(DE-Juel1)145110$$aLohmann, Philipp$$b4
000874448 7001_ $$0P:(DE-Juel1)144347$$aWilluweit, Antje$$b5
000874448 7001_ $$0P:(DE-Juel1)131818$$aErmert, Johannes$$b6
000874448 7001_ $$0P:(DE-Juel1)131816$$aCoenen, Heinrich Hubert$$b7
000874448 7001_ $$0P:(DE-Juel1)132318$$aMottaghy, Felix M.$$b8
000874448 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b9
000874448 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b10$$eCorresponding author
000874448 773__ $$0PERI:(DE-600)1498538-x$$a10.1016/j.nucmedbio.2020.02.006$$gp. S0969805120300299$$p78-84$$tNuclear medicine and biology$$v92$$x0969-8051$$y2021
000874448 8564_ $$uhttps://juser.fz-juelich.de/record/874448/files/1-s2.0-S0969805120300299-main.pdf
000874448 8564_ $$uhttps://juser.fz-juelich.de/record/874448/files/Stegmayr_2020_Post%20Print_Nucl%20Med%20Biol_Current%20trends%20in%20the%20use%20of%20FET_final_corr.pdf$$yPublished on 2020-02-19. Available in OpenAccess from 2021-02-19.
000874448 8564_ $$uhttps://juser.fz-juelich.de/record/874448/files/Stegmayr_2020_Post%20Print_Nucl%20Med%20Biol_Current%20trends%20in%20the%20use%20of%20FET_final_corr.pdf?subformat=pdfa$$xpdfa$$yPublished on 2020-02-19. Available in OpenAccess from 2021-02-19.
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