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@ARTICLE{Kleineberg:874449,
      author       = {Kleineberg, Nina N. and Richter, Monika K. and Becker,
                      Ingrid and Weiss-Blankenhorn, Peter and Fink, Gereon Rudolf},
      title        = {{V}erum versus sham t{DCS} in the treatment of
                      stroke-induced apraxia: study protocol of the randomized
                      controlled trial {RA}di{CS} -“{R}ehabilitating
                      (stroke-induced) {A}praxia with direct {C}urrent
                      {S}timulation”},
      journal      = {Neurological research and practice},
      volume       = {2},
      number       = {1},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2020-01450},
      pages        = {7},
      year         = {2020},
      abstract     = {IntroductionStroke is the leading cause of acquired
                      disability in western societies. (Motor) cognitive deficits
                      like apraxia significantly contribute to disability after
                      stroke, harming activities of daily living and
                      rehabilitation outcome. To date, efficient therapeutic
                      options for apraxia remain sparse. Thus, randomized
                      controlled trials (RCTs) are warranted.MethodsBased on
                      promising results of a pilot study, the on-going RAdiCS
                      (Rehabilitating stroke-induced Apraxia with direct Current
                      Stimulation) study is a randomized controlled trial, which
                      follows a double-blinded (investigator and patient), two-arm
                      parallel interventional model. It is designed to include 110
                      apraxic patients (as diagnosed by the Cologne Apraxia
                      Screening, KAS) in the subacute phase after a left
                      hemisphere (LH) stroke. The University of Cologne initiated
                      the trial, which is conducted in two German
                      Neurorehabilitation Centers.The study aims to evaluate the
                      effect of anodal (versus sham) transcranial direct current
                      stimulation (tDCS) applied over the left posterior parietal
                      cortex (PPC) with an intensity of 2 mA for 10 min on
                      five consecutive days on apraxic deficits. In addition to
                      anodal or sham tDCS, all LH stroke patients undergo a motor
                      (cognitive) training that is performed before and after the
                      stimulation (off-line stimulation).The primary outcome
                      measure is the (differential) change in the overall KAS
                      score after five daily sessions of anodal versus sham tDCS
                      when compared to the baseline assessment before tDCS.
                      Secondary study outcomes include further apraxia scores,
                      aphasia severity, and measures of motor performance and
                      disability after stroke. All outcome measures are obtained
                      in the post-stimulation assessment as well as during
                      follow-up (3–4 months after tDCS).},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33324913},
      UT           = {WOS:001050015600001},
      doi          = {10.1186/s42466-020-0052-y},
      url          = {https://juser.fz-juelich.de/record/874449},
}