000874486 001__ 874486
000874486 005__ 20210130004711.0
000874486 0247_ $$2doi$$a10.3389/fnana.2020.00002
000874486 0247_ $$2Handle$$a2128/24540
000874486 0247_ $$2altmetric$$aaltmetric:74501734
000874486 0247_ $$2pmid$$apmid:32116573
000874486 0247_ $$2WOS$$aWOS:000517116500001
000874486 037__ $$aFZJ-2020-01465
000874486 082__ $$a610
000874486 1001_ $$0P:(DE-Juel1)173630$$aWojtasik, Magdalena$$b0$$eCorresponding author
000874486 245__ $$aCytoarchitectonic Characterization and Functional Decoding of Four New Areas in the Human Lateral Orbitofrontal Cortex
000874486 260__ $$aLausanne$$bFrontiers Research Foundation$$c2020
000874486 3367_ $$2DRIVER$$aarticle
000874486 3367_ $$2DataCite$$aOutput Types/Journal article
000874486 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1584536158_22059
000874486 3367_ $$2BibTeX$$aARTICLE
000874486 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000874486 3367_ $$00$$2EndNote$$aJournal Article
000874486 500__ $$aWe thank Prof. Karl Zilles and Prof. Rüdiger Seitz for their continuous input and support throughout the whole project time. Special thanks also go out to Julia Camilleri for her assistance and help.
000874486 520__ $$aA comprehensive concept of the biological basis of reward, social and emotional behavior, and language requires a deeper understanding of the microstructure and connectivity of the underlying brain regions. Such understanding could provide deeper insights into their role in functional networks, and form the anatomical basis of the functional segregation of this region as shown in recent in vivo imaging studies. Here, we investigated the cytoarchitecture of the lateral orbitofrontal cortex (lateral OFC) in serial histological sections of 10 human postmortem brains by image analysis and a statistically reproducible approach to detect borders between cortical areas. Profiles of the volume fraction of cell bodies were therefore extracted from digitized histological images, describing laminar changes from the layer I/layer II boundary to the white matter. As a result, four new areas, Fo4–7, were identified. Area Fo4 was mainly found in the anterior orbital gyrus (AOG), Fo5 anteriorly in the inferior frontal gyrus (IFG), Fo6 in the lateral orbital gyrus (LOG), and Fo7 in the lateral orbital sulcus. Areas differed in cortical thickness, abundance and size of pyramidal cells in layer III and degree of granularity in layer IV. A hierarchical cluster analysis was used to quantify cytoarchitectonic differences between them. The 3D-reconstructed areas were transformed into the single-subject template of the Montreal Neurological Institute (MNI), where probabilistic maps and a maximum probability map (MPM) were calculated as part of the JuBrain Cytoarchitectonic Atlas. These maps served as reference data to study the functional properties of the areas using the BrainMap database. The type of behavioral tasks that activated them was analyzed to get first insights of co-activation patterns of the lateral OFC and its contribution to cognitive networks. Meta-analytic connectivity modeling (MACM) showed that functional decoding revealed activation in gustatory perception in Fo4; reward and somesthetic perception in Fo5; semantic processing and pain perception in Fo6; and emotional processing and covert reading in Fo7. Together with existing maps of the JuBrain Cytoarchitectonic Atlas, the new maps can now be used as an open-source reference for neuroimaging studies, allowing to further decode brain function.
000874486 536__ $$0G:(DE-HGF)POF3-571$$a571 - Connectivity and Activity (POF3-571)$$cPOF3-571$$fPOF III$$x0
000874486 536__ $$0G:(EU-Grant)785907$$aHBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907)$$c785907$$fH2020-SGA-FETFLAG-HBP-2017$$x1
000874486 588__ $$aDataset connected to CrossRef
000874486 7001_ $$0P:(DE-Juel1)131636$$aBludau, Sebastian$$b1$$ufzj
000874486 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b2$$ufzj
000874486 7001_ $$0P:(DE-Juel1)131660$$aMohlberg, Hartmut$$b3$$ufzj
000874486 7001_ $$0P:(DE-HGF)0$$aGerboga, Fatma$$b4
000874486 7001_ $$0P:(DE-Juel1)131675$$aCaspers, Svenja$$b5$$ufzj
000874486 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b6$$ufzj
000874486 773__ $$0PERI:(DE-600)2452969-2$$a10.3389/fnana.2020.00002$$gVol. 14, p. 2$$p2$$tFrontiers in neuroanatomy$$v14$$x1662-5129$$y2020
000874486 8564_ $$uhttps://juser.fz-juelich.de/record/874486/files/fnana-14-00002.pdf$$yOpenAccess
000874486 8564_ $$uhttps://juser.fz-juelich.de/record/874486/files/fnana-14-00002.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000874486 909CO $$ooai:juser.fz-juelich.de:874486$$pdnbdelivery$$pec_fundedresources$$pVDB$$pdriver$$popen_access$$popenaire
000874486 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131636$$aForschungszentrum Jülich$$b1$$kFZJ
000874486 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b2$$kFZJ
000874486 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131660$$aForschungszentrum Jülich$$b3$$kFZJ
000874486 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131675$$aForschungszentrum Jülich$$b5$$kFZJ
000874486 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131631$$aForschungszentrum Jülich$$b6$$kFZJ
000874486 9131_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000874486 9141_ $$y2020
000874486 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000874486 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000874486 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000874486 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT NEUROANAT : 2017
000874486 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000874486 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000874486 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000874486 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000874486 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000874486 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000874486 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review
000874486 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000874486 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000874486 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000874486 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000874486 920__ $$lyes
000874486 9201_ $$0I:(DE-Juel1)INM-1-20090406$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x0
000874486 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x1
000874486 980__ $$ajournal
000874486 980__ $$aVDB
000874486 980__ $$aI:(DE-Juel1)INM-1-20090406
000874486 980__ $$aI:(DE-Juel1)INM-7-20090406
000874486 980__ $$aUNRESTRICTED
000874486 9801_ $$aFullTexts