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@ARTICLE{vonPolier:874552,
      author       = {von Polier, Georg G. and Greimel, Ellen and Konrad, Kerstin
                      and Großheinrich, Nicola and Kohls, Gregor and Vloet, Timo
                      D. and Herpertz-Dahlmann, Beate and Schulte-Rüther, Martin},
      title        = {{N}eural {C}orrelates of {E}mpathy in {B}oys {W}ith {E}arly
                      {O}nset {C}onduct {D}isorder},
      journal      = {Frontiers in psychiatry},
      volume       = {11},
      issn         = {1664-0640},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2020-01506},
      pages        = {178},
      year         = {2020},
      abstract     = {Background: A deficit in empathy has repeatedly been
                      described in individuals with conduct disorder (CD), and in
                      particular in those with callous unemotional traits. Until
                      now, little is known about the neural basis of empathy in
                      children and adolescents with early onset conduct disorder.
                      The aim of this study was to examine neural responses during
                      empathizing in children and adolescents with CD with a task
                      that allowed to differentiate between the judgment of the
                      emotional states of other people and the own emotional
                      response to other people's emotional state. Moreover, we
                      investigated associations of callous-unemotional traits and
                      neural activations during empathizing.Methods: Using
                      functional magnetic resonance imaging (fMRI) we investigated
                      14 boys with early onset CD and 15 typically developing
                      (TDC) age matched controls between 8 and 16 years of age.
                      Happy and sad faces were presented, and participants were
                      asked to either infer the emotional state from the face
                      (other-task) or to judge their own emotional response
                      (self-task). A perceptual decision on faces was used as a
                      control task. Individual empathic abilities and callous
                      unemotional traits were assessed.Results: During the other
                      task, TDC boys showed significantly larger right amygdala
                      responses than CD boys. Higher empathic abilities (as
                      assessed with the Bryant Index of Empathy) were associated
                      with higher responses in the right amygdala within the CD
                      boys and across the entire sample. Moreover, across the
                      entire sample, callous-unemotional traits were negatively
                      related to the BOLD-response in the right amygdala. CD boys
                      showed larger responses in the dorsal and ventral medial
                      prefrontal cortex across tasks and increased activation in
                      dorsal medial prefrontal cortex specifically during the
                      self-conditions, which were also related to empathic
                      abilities within the CD boys.Conclusions: The data emphasize
                      the important role of the amygdala in empathy related
                      emotional processing. Diminished amygdala responses and
                      their association with low empathy suggest a pivotal
                      influence of impaired amygdala processing in early-onset CD,
                      in particular for deficits in empathic behavior and related
                      callous-unemotional-traits. Elevated response in the medial
                      prefrontal cortex in boys with CD point toward increased
                      involvement of brain areas related to self-referential
                      processing and cognitive empathy during empathizing.},
      cin          = {INM-7 / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-11-20170113},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32256406},
      UT           = {WOS:000525657100001},
      doi          = {10.3389/fpsyt.2020.00178},
      url          = {https://juser.fz-juelich.de/record/874552},
}