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@ARTICLE{Yu:874556,
      author       = {Yu, Qingfen and Dasgupta, Sabyasachi and Auth, Thorsten and
                      Gompper, Gerhard},
      title        = {{O}smotic {C}oncentration-{C}ontrolled {P}article {U}ptake
                      and {W}rapping-{I}nduced {L}ysis of {C}ells and {V}esicles},
      journal      = {Nano letters},
      volume       = {20},
      number       = {3},
      issn         = {1530-6992},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {FZJ-2020-01510},
      pages        = {1662 - 1668},
      year         = {2020},
      abstract     = {In vivo, high protein and ion concentrations determine the
                      preferred volumes of cells, organelles, and vesicles.
                      Deformations of their lipid-bilayer membranes by
                      nanoparticle wrapping reduce the interior volumes available
                      to solutes and thus induce large osmotic pressure
                      differences. Osmotic concentration can therefore be an
                      important control parameter for wrapping of nanoparticles.
                      We employ a curvature-elasticity model of the membrane and
                      contact interaction with spherical particles to study their
                      wrapping at initially spherical vesicles. Although the
                      continuous particle-binding transition is independent of the
                      presence of solutes, the discontinuous envelopment
                      transition shifts to higher adhesion strengths and the
                      corresponding energy barrier increases with increasing
                      osmotic concentration. High osmotic concentrations stabilize
                      partial-wrapped, membrane-bound states for both, particle
                      attachment to the inside and the outside. In this regime,
                      wrapping of particles controls membrane tension, with
                      power-law dependencies on osmotic concentration and adhesion
                      strength. For high adhesion strengths, particle wrapping can
                      lead to the opening of mechanosensitive channels in cell
                      membranes and to lysis. Membrane tension-induced
                      stabilization of partial-wrapped states as well as
                      wrapping-induced lysis play important roles not only for
                      desired mechano-bacteriocidal effects of engineered
                      nanomaterials but may also determine viral burst sizes of
                      bacteria and control endocytosis for mammalian cells.},
      cin          = {IBI-5},
      ddc          = {660},
      cid          = {I:(DE-Juel1)IBI-5-20200312},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32046489},
      UT           = {WOS:000526408800025},
      doi          = {10.1021/acs.nanolett.9b04788},
      url          = {https://juser.fz-juelich.de/record/874556},
}