TY  - JOUR
AU  - Sripad, Praveen
AU  - Rosenberg, Jessica
AU  - Boers, Frank
AU  - Filss, Christian P.
AU  - Galldiks, Norbert
AU  - Langen, Karl-Josef
AU  - Clauss, Ralf
AU  - Shah, N. Jon
AU  - Dammers, Jürgen
TI  - Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
JO  - Case reports in neurological medicine
VL  - 2020
SN  - 2090-6676
CY  - New York, NY
PB  - Hindawi
M1  - FZJ-2020-01568
SP  - 1 - 8
PY  - 2020
AB  - In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson’s disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4–12 Hz) and lower beta (15–20 Hz) frequency bands. An increase in power after zolpidem intake was found in the higher beta/lower gamma (20–43 Hz) frequency band. Source level functional connectivity measured using weighted-phase lag index showed changes after zolpidem intake. Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. MEG is an informative and sensitive tool to detect changes in brain activity for TBI.
LB  - PUB:(DE-HGF)16
C6  - pmid:32257474
UR  - <Go to ISI:>//WOS:000522949400001
DO  - DOI:10.1155/2020/8597062
UR  - https://juser.fz-juelich.de/record/874650
ER  -