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@ARTICLE{Aswendt:874714,
      author       = {Aswendt, Markus and Pallast, Niklas and Wieters, Frederique
                      and Baues, Mayan and Hoehn, Mathias and Fink, Gereon R},
      title        = {{L}esion {S}ize- and {L}ocation-{D}ependent {R}ecruitment
                      of {C}ontralesional {T}halamus and {M}otor {C}ortex
                      {F}acilitates {R}ecovery after {S}troke in {M}ice},
      journal      = {Translational stroke research},
      volume       = {12},
      issn         = {1868-601X},
      address      = {New York, NY},
      publisher    = {Springer},
      reportid     = {FZJ-2020-01626},
      pages        = {87-97},
      year         = {2021},
      abstract     = {Brain lesions caused by cerebral ischemia or hemorrhage
                      lead to a local breakdown of energy homeostasis followed by
                      irreversible cell death and long-term impairment.
                      Importantly, local brain lesions also generate remote
                      functional and structural disturbances, which contribute to
                      the behavioral deficit but also impact the recovery of
                      function. While spontaneous recovery has been associated
                      with endogenous repair mechanisms at the vascular, neural,
                      and immune cell levels, the impact of structural plasticity
                      on sensory-motor dysfunction and recovery thereof remains to
                      be elucidated by longitudinal imaging in a mouse model.
                      Here, we applied behavioral assessments, in vivo fiber
                      tracking, and histological validation in a photothrombotic
                      stroke mouse model. Atlas-based whole-brain structural
                      connectivity analysis and ex vivo histology revealed
                      secondary neurodegeneration in the ipsilesional brain areas,
                      mostly in the dorsal sensorimotor area of the thalamus.
                      Furthermore, we describe for the first time a lesion
                      size-dependent increase in structural connectivity between
                      the contralesional primary motor cortex and thalamus with
                      the ipsilesional cortex. The involvement of the
                      contralesional hemisphere was associated with improved
                      functional recovery relative to lesion size. This study
                      highlights the importance of in vivo fiber tracking and the
                      role of the contralesional hemisphere during spontaneous
                      functional improvement as a potential novel stroke biomarker
                      and therapeutic targets.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572) / 5252 -
                      Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF3-572 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32166716},
      UT           = {WOS:000563916500001},
      doi          = {10.1007/s12975-020-00802-3},
      url          = {https://juser.fz-juelich.de/record/874714},
}