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000874715 1001_ $$00000-0001-7023-146X$$aDembek, Till A.$$b0$$eCorresponding author
000874715 245__ $$aPSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract
000874715 260__ $$a[Amsterdam u.a.]$$bElsevier$$c2020
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000874715 520__ $$aObjectiveTo investigate the relation between deep brain stimulation (DBS) of the posterior-subthalamic-area (PSA) and the ventral-intermediate-nucleus (VIM) and the distance to the dentatorubrothalamic tract (DRTT) in essential tremor (ET).MethodsTremor rating scale (TRS) hemi-scores were analyzed in 13 ET patients, stimulated in both the VIM and the PSA in a randomized, crossover trial. Distances of PSA and VIM contacts to population-based DRTTs were calculated. The relationships between distance to DRTT and stimulation amplitude, as well as DBS efficiency (TRS improvement per amplitude) were investigated.ResultsPSA contacts were closer to the DRTT (p = 0.019) and led to a greater improvement in TRS hemi-scores (p = 0.005) than VIM contacts. Proximity to the DRTT was related to lower amplitudes (p < 0.001) and higher DBS efficiency (p = 0.017).ConclusionsDifferences in tremor outcome and stimulation parameters between contacts in the PSA and the VIM can be explained by their different distance to the DRTT.
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000874715 7001_ $$00000-0003-0749-3840$$aPetry-Schmelzer, Jan Niklas$$b1
000874715 7001_ $$0P:(DE-HGF)0$$aReker, Paul$$b2
000874715 7001_ $$0P:(DE-HGF)0$$aWirths, Jochen$$b3
000874715 7001_ $$0P:(DE-HGF)0$$aHamacher, Stefanie$$b4
000874715 7001_ $$0P:(DE-HGF)0$$aSteffen, Julia$$b5
000874715 7001_ $$0P:(DE-HGF)0$$aDafsari, Haidar S.$$b6
000874715 7001_ $$0P:(DE-HGF)0$$aHövels, Mauritius$$b7
000874715 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b8$$ufzj
000874715 7001_ $$0P:(DE-HGF)0$$aVisser-Vandewalle, Veerle$$b9
000874715 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b10
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